Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior

Courtship is pivotal to successful reproduction throughout the animal kingdom. Sexual differences in the nervous system are thought to underlie courtship behavior. Male courtship behavior in Drosophila is in large part regulated by the gene fruitless (fru). fru has been reported to encode at least t...

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Main Authors:	Nojima, Tetsuya, Neville, Megan C, Goodwin, Stephen F
Format:	Online
Language:	English
Published:	Landes Bioscience 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197022/

id	pubmed-4197022
recordtype	oai_dc
spelling	pubmed-41970222015-12-04 Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior Nojima, Tetsuya Neville, Megan C Goodwin, Stephen F Extra View Courtship is pivotal to successful reproduction throughout the animal kingdom. Sexual differences in the nervous system are thought to underlie courtship behavior. Male courtship behavior in Drosophila is in large part regulated by the gene fruitless (fru). fru has been reported to encode at least three putative BTB-zinc-finger transcription factors predicted to have different DNA-binding specificities. Although a large number of previous studies have demonstrated that fru plays essential roles in male courtship behavior, we know little about the function of Fru isoforms at the molecular level. Our recent study revealed that male-specific Fru isoforms are expressed in highly overlapping subsets of neurons in the male brain and ventral nerve cord. Fru isoforms play both distinct and redundant roles in male courtship behavior. Importantly, we have identified for the first time, by means of the DamID technique, direct Fru transcriptional target genes. Fru target genes overwhelmingly represent genes previously reported to be involved in the nervous system development, such as CadN, lola and pdm2. Our study provides important insight into how the sexually dimorphic neural circuits underlying reproductive behavior are established. Landes Bioscience 2014-04-01 2014-05-09 /pmc/articles/PMC4197022/ /pubmed/25483248 http://dx.doi.org/10.4161/fly.29132 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nojima, Tetsuya Neville, Megan C Goodwin, Stephen F
spellingShingle	Nojima, Tetsuya Neville, Megan C Goodwin, Stephen F Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior
author_facet	Nojima, Tetsuya Neville, Megan C Goodwin, Stephen F
author_sort	Nojima, Tetsuya
title	Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior
title_short	Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior
title_full	Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior
title_fullStr	Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior
title_full_unstemmed	Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior
title_sort	fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying drosophila reproductive behavior
description	Courtship is pivotal to successful reproduction throughout the animal kingdom. Sexual differences in the nervous system are thought to underlie courtship behavior. Male courtship behavior in Drosophila is in large part regulated by the gene fruitless (fru). fru has been reported to encode at least three putative BTB-zinc-finger transcription factors predicted to have different DNA-binding specificities. Although a large number of previous studies have demonstrated that fru plays essential roles in male courtship behavior, we know little about the function of Fru isoforms at the molecular level. Our recent study revealed that male-specific Fru isoforms are expressed in highly overlapping subsets of neurons in the male brain and ventral nerve cord. Fru isoforms play both distinct and redundant roles in male courtship behavior. Importantly, we have identified for the first time, by means of the DamID technique, direct Fru transcriptional target genes. Fru target genes overwhelmingly represent genes previously reported to be involved in the nervous system development, such as CadN, lola and pdm2. Our study provides important insight into how the sexually dimorphic neural circuits underlying reproductive behavior are established.
publisher	Landes Bioscience
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197022/
_version_	1613144772450451456

Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior

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