Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice

Bone metastasis is a lethal and morbid late stage of breast cancer that is currently treatment resistant. More effective mouse models and treatment are necessary. High bone-metastatic variants of human breast cancer cells were selected in nude mice by cardiac injection. After cardiac injection of a...

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Main Authors:	Miwa, Shinji, Yano, Shuya, Zhang, Yong, Matsumoto, Yasunori, Uehara, Fuminari, Yamamoto, Mako, Hiroshima, Yukihiko, Kimura, Hiroaki, Hayashi, Katsuhiro, Yamamoto, Norio, Bouvet, Michael, Tsuchiya, Hiroyuki, Hoffman, Robert M., Zhao, Ming
Format:	Online
Language:	English
Published:	Impact Journals LLC 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196188/

id	pubmed-4196188
recordtype	oai_dc
spelling	pubmed-41961882014-10-21 Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice Miwa, Shinji Yano, Shuya Zhang, Yong Matsumoto, Yasunori Uehara, Fuminari Yamamoto, Mako Hiroshima, Yukihiko Kimura, Hiroaki Hayashi, Katsuhiro Yamamoto, Norio Bouvet, Michael Tsuchiya, Hiroyuki Hoffman, Robert M. Zhao, Ming Research Paper Bone metastasis is a lethal and morbid late stage of breast cancer that is currently treatment resistant. More effective mouse models and treatment are necessary. High bone-metastatic variants of human breast cancer cells were selected in nude mice by cardiac injection. After cardiac injection of a high bone-metastatic variant of breast cancer, all untreated mice had bone metastases compared to only 20% with parental cells. Treatment with tumor-targeting Salmonella typhimurium A1-R completely prevented the appearance of bone metastasis of the high metastatic variant in nude mice (P < 0.001). After injection of the highly bone-metastatic breast cancer variant to the tibia of nude mice, S. typhimurium A1-R treatment significantly reduced tumor growth in the bone (P < 0.001). These data indicated that S. typhimurium A1-R is useful to prevent and inhibit breast cancer bone metastasis and should be of future clinical use for breast cancer in the adjuvant setting. Impact Journals LLC 2014-07-16 /pmc/articles/PMC4196188/ /pubmed/25216526 Text en Copyright: © 2014 Miwa et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Miwa, Shinji Yano, Shuya Zhang, Yong Matsumoto, Yasunori Uehara, Fuminari Yamamoto, Mako Hiroshima, Yukihiko Kimura, Hiroaki Hayashi, Katsuhiro Yamamoto, Norio Bouvet, Michael Tsuchiya, Hiroyuki Hoffman, Robert M. Zhao, Ming
spellingShingle	Miwa, Shinji Yano, Shuya Zhang, Yong Matsumoto, Yasunori Uehara, Fuminari Yamamoto, Mako Hiroshima, Yukihiko Kimura, Hiroaki Hayashi, Katsuhiro Yamamoto, Norio Bouvet, Michael Tsuchiya, Hiroyuki Hoffman, Robert M. Zhao, Ming Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice
author_facet	Miwa, Shinji Yano, Shuya Zhang, Yong Matsumoto, Yasunori Uehara, Fuminari Yamamoto, Mako Hiroshima, Yukihiko Kimura, Hiroaki Hayashi, Katsuhiro Yamamoto, Norio Bouvet, Michael Tsuchiya, Hiroyuki Hoffman, Robert M. Zhao, Ming
author_sort	Miwa, Shinji
title	Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice
title_short	Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice
title_full	Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice
title_fullStr	Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice
title_full_unstemmed	Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice
title_sort	tumor-targeting salmonella typhimurium a1-r prevents experimental human breast cancer bone metastasis in nude mice
description	Bone metastasis is a lethal and morbid late stage of breast cancer that is currently treatment resistant. More effective mouse models and treatment are necessary. High bone-metastatic variants of human breast cancer cells were selected in nude mice by cardiac injection. After cardiac injection of a high bone-metastatic variant of breast cancer, all untreated mice had bone metastases compared to only 20% with parental cells. Treatment with tumor-targeting Salmonella typhimurium A1-R completely prevented the appearance of bone metastasis of the high metastatic variant in nude mice (P < 0.001). After injection of the highly bone-metastatic breast cancer variant to the tibia of nude mice, S. typhimurium A1-R treatment significantly reduced tumor growth in the bone (P < 0.001). These data indicated that S. typhimurium A1-R is useful to prevent and inhibit breast cancer bone metastasis and should be of future clinical use for breast cancer in the adjuvant setting.
publisher	Impact Journals LLC
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196188/
_version_	1613144487365705728

Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice

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