Relationship between Lung Function and Metabolic Syndrome

Relationship between Lung Function and Metabolic Syndrome

Although the link between impaired lung function and cardiovascular events and type 2 diabetes mellitus has been recognized, the association between impaired lung function and metabolic syndrome has not been comprehensively assessed in the United States (U.S.) population. The aim of our study was to...

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Main Authors: Chen, Wei-Liang, Wang, Chung-Ching, Wu, Li-Wei, Kao, Tung-Wei, Chan, James Yi-Hsin, Chen, Ying-Jen, Yang, Ya-Hui, Chang, Yaw-Wen, Peng, Tao-Chun
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191965/
id pubmed-4191965
recordtype oai_dc
spelling pubmed-41919652014-10-14 Relationship between Lung Function and Metabolic Syndrome Chen, Wei-Liang Wang, Chung-Ching Wu, Li-Wei Kao, Tung-Wei Chan, James Yi-Hsin Chen, Ying-Jen Yang, Ya-Hui Chang, Yaw-Wen Peng, Tao-Chun Research Article Although the link between impaired lung function and cardiovascular events and type 2 diabetes mellitus has been recognized, the association between impaired lung function and metabolic syndrome has not been comprehensively assessed in the United States (U.S.) population. The aim of our study was to explore the association between impaired lung function and metabolic syndrome in a nationally representative sample of men and women. This cross-sectional population-based study included 8602 participants aged 20–65 years in the Third National Health and Nutrition Examination Survey (NHANES III). We examined the relationship between the different features of metabolic syndrome and lung function, including forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). After adjusting for potential confounders such as age, body mass index, inflammatory factors, medical condition, and smoking status, participants with more components of metabolic syndrome had lower predicted values of FVC and FEV1 (p for trend <0.001 for both). Impaired pulmonary function was also associated with individual components of metabolic syndrome, such as abdominal obesity, high blood pressure, high triglycerides, and low high density lipoprotein (HDL) cholesterol (p<0.05 for all parameters). These results from a nationally representative sample of US adults suggest that a greater number of features of metabolic syndrome is strongly associated with poorer FVC and FEV1. In clinical practice, more comprehensive management strategies to address subjects with metabolic syndrome and impaired lung function need to be developed and investigated. Public Library of Science 2014-10-09 /pmc/articles/PMC4191965/ /pubmed/25299452 http://dx.doi.org/10.1371/journal.pone.0108989 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Chen, Wei-Liang
Wang, Chung-Ching
Wu, Li-Wei
Kao, Tung-Wei
Chan, James Yi-Hsin
Chen, Ying-Jen
Yang, Ya-Hui
Chang, Yaw-Wen
Peng, Tao-Chun
spellingShingle Chen, Wei-Liang
Wang, Chung-Ching
Wu, Li-Wei
Kao, Tung-Wei
Chan, James Yi-Hsin
Chen, Ying-Jen
Yang, Ya-Hui
Chang, Yaw-Wen
Peng, Tao-Chun
Relationship between Lung Function and Metabolic Syndrome
author_facet Chen, Wei-Liang
Wang, Chung-Ching
Wu, Li-Wei
Kao, Tung-Wei
Chan, James Yi-Hsin
Chen, Ying-Jen
Yang, Ya-Hui
Chang, Yaw-Wen
Peng, Tao-Chun
author_sort Chen, Wei-Liang
title Relationship between Lung Function and Metabolic Syndrome
title_short Relationship between Lung Function and Metabolic Syndrome
title_full Relationship between Lung Function and Metabolic Syndrome
title_fullStr Relationship between Lung Function and Metabolic Syndrome
title_full_unstemmed Relationship between Lung Function and Metabolic Syndrome
title_sort relationship between lung function and metabolic syndrome
description Although the link between impaired lung function and cardiovascular events and type 2 diabetes mellitus has been recognized, the association between impaired lung function and metabolic syndrome has not been comprehensively assessed in the United States (U.S.) population. The aim of our study was to explore the association between impaired lung function and metabolic syndrome in a nationally representative sample of men and women. This cross-sectional population-based study included 8602 participants aged 20–65 years in the Third National Health and Nutrition Examination Survey (NHANES III). We examined the relationship between the different features of metabolic syndrome and lung function, including forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). After adjusting for potential confounders such as age, body mass index, inflammatory factors, medical condition, and smoking status, participants with more components of metabolic syndrome had lower predicted values of FVC and FEV1 (p for trend <0.001 for both). Impaired pulmonary function was also associated with individual components of metabolic syndrome, such as abdominal obesity, high blood pressure, high triglycerides, and low high density lipoprotein (HDL) cholesterol (p<0.05 for all parameters). These results from a nationally representative sample of US adults suggest that a greater number of features of metabolic syndrome is strongly associated with poorer FVC and FEV1. In clinical practice, more comprehensive management strategies to address subjects with metabolic syndrome and impaired lung function need to be developed and investigated.
publisher Public Library of Science
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191965/
_version_ 1613142781535977472

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