A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response

A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response

The Replication Stress Response (RSR) is a signaling network that recognizes challenges to DNA replication and coordinates diverse DNA repair and cell-cycle checkpoint pathways. Gemcitabine is a nucleoside analogue that causes cytotoxicity by inducing DNA replication blocks. Using a synthetic lethal...

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Bibliographic Details
Main Authors: Smith, Scott C., Petrova, Aleksandra V., Madden, Matthew Z., Wang, Hongyan, Pan, Yunfeng, Warren, Matthew D., Hardy, Claire W., Liang, Dong, Liu, Elaine A., Robinson, M. Hope, Rudra, Soumon, Wang, Jie, Ehdaivand, Shahrzad, Torres, Mylin A., Wang, Ya, Yu, David S.
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191414/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191414/

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