Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens

Plant resistance (R) proteins perceive specific pathogen effectors from diverse plant pathogens to initiate defense responses, designated effector-triggered immunity (ETI). Plant R proteins are mostly nucleotide binding-leucine rich repeat (NB-LRR) proteins, which recognize pathogen effectors direct...

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Main Authors:	Wu, Liang, Chen, Huan, Curtis, Chad, Fu, Zheng Qing
Format:	Online
Language:	English
Published:	Landes Bioscience 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189877/

id	pubmed-4189877
recordtype	oai_dc
spelling	pubmed-41898772015-10-01 Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens Wu, Liang Chen, Huan Curtis, Chad Fu, Zheng Qing Review Plant resistance (R) proteins perceive specific pathogen effectors from diverse plant pathogens to initiate defense responses, designated effector-triggered immunity (ETI). Plant R proteins are mostly nucleotide binding-leucine rich repeat (NB-LRR) proteins, which recognize pathogen effectors directly or indirectly through sophisticated mechanisms. Upon activation by effector proteins, R proteins elicit robust defense responses, including a rapid burst of reactive oxygen species (ROS), induced biosynthesis and accumulation of salicylic acid (SA), a rapid programmed cell death (PCD) called hypersensitive response (HR) at the infection sites, and increased expression of pathogenesis-related (PR) genes. Initiation of ETI is correlated with a complex network of defense signaling pathways, resulting in defensive cellular responses and large-scale transcriptional reprogramming events. In this review, we highlight important recent advances on the recognition of effectors, regulation and activation of plant R proteins, dynamic intracellular trafficking of R proteins, induction of cell death, and transcriptional reprogramming associated with ETI. Current knowledge gaps and future research directions are also discussed in this review. Landes Bioscience 2014-10-01 2014-07-10 /pmc/articles/PMC4189877/ /pubmed/25513772 http://dx.doi.org/10.4161/viru.29755 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wu, Liang Chen, Huan Curtis, Chad Fu, Zheng Qing
spellingShingle	Wu, Liang Chen, Huan Curtis, Chad Fu, Zheng Qing Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens
author_facet	Wu, Liang Chen, Huan Curtis, Chad Fu, Zheng Qing
author_sort	Wu, Liang
title	Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens
title_short	Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens
title_full	Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens
title_fullStr	Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens
title_full_unstemmed	Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens
title_sort	go in for the kill: how plants deploy effector-triggered immunity to combat pathogens
description	Plant resistance (R) proteins perceive specific pathogen effectors from diverse plant pathogens to initiate defense responses, designated effector-triggered immunity (ETI). Plant R proteins are mostly nucleotide binding-leucine rich repeat (NB-LRR) proteins, which recognize pathogen effectors directly or indirectly through sophisticated mechanisms. Upon activation by effector proteins, R proteins elicit robust defense responses, including a rapid burst of reactive oxygen species (ROS), induced biosynthesis and accumulation of salicylic acid (SA), a rapid programmed cell death (PCD) called hypersensitive response (HR) at the infection sites, and increased expression of pathogenesis-related (PR) genes. Initiation of ETI is correlated with a complex network of defense signaling pathways, resulting in defensive cellular responses and large-scale transcriptional reprogramming events. In this review, we highlight important recent advances on the recognition of effectors, regulation and activation of plant R proteins, dynamic intracellular trafficking of R proteins, induction of cell death, and transcriptional reprogramming associated with ETI. Current knowledge gaps and future research directions are also discussed in this review.
publisher	Landes Bioscience
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189877/
_version_	1613142072532926464

Go in for the kill: How plants deploy effector-triggered immunity to combat pathogens

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