Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological characteristics, raising the question of whether an earlier, “naive” state of pluripotency may exist in humans. Here we took a systematic approach to identify small molecules that support self-renewal of naive huma...

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Bibliographic Details
Main Authors: Theunissen, Thorold W., Powell, Benjamin E., Wang, Haoyi, Mitalipova, Maya, Faddah, Dina A., Reddy, Jessica, Fan, Zi Peng, Maetzel, Dorothea, Ganz, Kibibi, Shi, Linyu, Lungjangwa, Tenzin, Imsoonthornruksa, Sumeth, Stelzer, Yonatan, Rangarajan, Sudharshan, D’Alessio, Ana, Zhang, Jianming, Gao, Qing, Dawlaty, Meelad M., Young, Richard A., Gray, Nathanael S., Jaenisch, Rudolf
Format: Online
Language:English
Published: Cell Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184977/