μ-Opioid activation in the midbrain during migraine allodynia – brief report II

We investigated in vivo the allodynic response of the central μ-opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomogra...

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Main Authors:	Nascimento, Thiago D, DosSantos, Marcos F, Lucas, Sarah, van Holsbeeck, Hendrik, DeBoer, Misty, Maslowski, Eric, Love, Tiffany, Martikainen, Ilkka K, Koeppe, Robert A, Smith, Yolanda R, Zubieta, Jon-Kar, DaSilva, Alexandre F
Format:	Online
Language:	English
Published:	Blackwell Publishing Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184673/

id	pubmed-4184673
recordtype	oai_dc
spelling	pubmed-41846732014-10-29 μ-Opioid activation in the midbrain during migraine allodynia – brief report II Nascimento, Thiago D DosSantos, Marcos F Lucas, Sarah van Holsbeeck, Hendrik DeBoer, Misty Maslowski, Eric Love, Tiffany Martikainen, Ilkka K Koeppe, Robert A Smith, Yolanda R Zubieta, Jon-Kar DaSilva, Alexandre F Brief Communications We investigated in vivo the allodynic response of the central μ-opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. Females were scanned during the mid-late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μOR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μOR activation in the migraineurs' brains in response to their allodynic experience. Blackwell Publishing Ltd 2014-06 2014-06-01 /pmc/articles/PMC4184673/ /pubmed/25328905 http://dx.doi.org/10.1002/acn3.66 Text en © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nascimento, Thiago D DosSantos, Marcos F Lucas, Sarah van Holsbeeck, Hendrik DeBoer, Misty Maslowski, Eric Love, Tiffany Martikainen, Ilkka K Koeppe, Robert A Smith, Yolanda R Zubieta, Jon-Kar DaSilva, Alexandre F
spellingShingle	Nascimento, Thiago D DosSantos, Marcos F Lucas, Sarah van Holsbeeck, Hendrik DeBoer, Misty Maslowski, Eric Love, Tiffany Martikainen, Ilkka K Koeppe, Robert A Smith, Yolanda R Zubieta, Jon-Kar DaSilva, Alexandre F μ-Opioid activation in the midbrain during migraine allodynia – brief report II
author_facet	Nascimento, Thiago D DosSantos, Marcos F Lucas, Sarah van Holsbeeck, Hendrik DeBoer, Misty Maslowski, Eric Love, Tiffany Martikainen, Ilkka K Koeppe, Robert A Smith, Yolanda R Zubieta, Jon-Kar DaSilva, Alexandre F
author_sort	Nascimento, Thiago D
title	μ-Opioid activation in the midbrain during migraine allodynia – brief report II
title_short	μ-Opioid activation in the midbrain during migraine allodynia – brief report II
title_full	μ-Opioid activation in the midbrain during migraine allodynia – brief report II
title_fullStr	μ-Opioid activation in the midbrain during migraine allodynia – brief report II
title_full_unstemmed	μ-Opioid activation in the midbrain during migraine allodynia – brief report II
title_sort	μ-opioid activation in the midbrain during migraine allodynia – brief report ii
description	We investigated in vivo the allodynic response of the central μ-opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. Females were scanned during the mid-late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μOR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μOR activation in the migraineurs' brains in response to their allodynic experience.
publisher	Blackwell Publishing Ltd
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184673/
_version_	1613140764513009664

μ-Opioid activation in the midbrain during migraine allodynia – brief report II

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