Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection

Intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) therapy is being increasingly employed as an alternative to surgical intervention for the treatment of complicated parapneumonic effusions and empyema. Published cases are limited to one randomized control trial and few ca...

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Main Authors:	Popowicz, Natalia, Piccolo, Francesco, Shrestha, Ranjan, Lee, Y C Gary
Format:	Online
Language:	English
Published:	BlackWell Publishing Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184516/

id	pubmed-4184516
recordtype	oai_dc
spelling	pubmed-41845162014-12-03 Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection Popowicz, Natalia Piccolo, Francesco Shrestha, Ranjan Lee, Y C Gary Case Reports Intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) therapy is being increasingly employed as an alternative to surgical intervention for the treatment of complicated parapneumonic effusions and empyema. Published cases are limited to one randomized control trial and few case reports. No data exist on employing sequential or repeated courses of intrapleural tPA/DNase to aid evacuation of separate collections in patients' with a multiloculated pleural infection. This is the first report of successful use of sequential delivery of separate courses of intrapleural tPA/DNase to two noncommunicating infected pleural fluid collections within the same hemithorax of a patient. Our case confirms that prior treatment with tPA/DNase therapy does not preclude subsequent effective and safe use of this intrapleural treatment. BlackWell Publishing Ltd 2014-06 2014-05-04 /pmc/articles/PMC4184516/ /pubmed/25473577 http://dx.doi.org/10.1002/rcr2.58 Text en © 2014 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Popowicz, Natalia Piccolo, Francesco Shrestha, Ranjan Lee, Y C Gary
spellingShingle	Popowicz, Natalia Piccolo, Francesco Shrestha, Ranjan Lee, Y C Gary Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection
author_facet	Popowicz, Natalia Piccolo, Francesco Shrestha, Ranjan Lee, Y C Gary
author_sort	Popowicz, Natalia
title	Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection
title_short	Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection
title_full	Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection
title_fullStr	Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection
title_full_unstemmed	Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection
title_sort	two sequential tpa/dnase courses for noncommunicating loculated collections in pleural infection
description	Intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) therapy is being increasingly employed as an alternative to surgical intervention for the treatment of complicated parapneumonic effusions and empyema. Published cases are limited to one randomized control trial and few case reports. No data exist on employing sequential or repeated courses of intrapleural tPA/DNase to aid evacuation of separate collections in patients' with a multiloculated pleural infection. This is the first report of successful use of sequential delivery of separate courses of intrapleural tPA/DNase to two noncommunicating infected pleural fluid collections within the same hemithorax of a patient. Our case confirms that prior treatment with tPA/DNase therapy does not preclude subsequent effective and safe use of this intrapleural treatment.
publisher	BlackWell Publishing Ltd
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184516/
_version_	1613140679971569664

Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection

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