Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting

Backround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG. Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed pr...

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Main Authors:	Mentese, Umit, Dogan, Orhan Veli, Turan, Ibrahim, Usta, Sefer, Dogan, Emre, Oztas Mentese, Seda, Demir, Selim, Ozer, Tanil, Aykan, Ahmet Cagri, Alver, Ahmet
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181498/

id	pubmed-4181498
recordtype	oai_dc
spelling	pubmed-41814982014-10-09 Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting Mentese, Umit Dogan, Orhan Veli Turan, Ibrahim Usta, Sefer Dogan, Emre Oztas Mentese, Seda Demir, Selim Ozer, Tanil Aykan, Ahmet Cagri Alver, Ahmet Clinical Study Backround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG. Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed preoperatively, at 20 minutes after aortic clamping and at 30 minutes, 6 hours, and 48 hours after declamping (reperfusion). The patients were divided into 2 groups according to the median aortic cross clamping (XC) time: group 1 (XC time < 42 minutes) and group 2 (XC time ≥ 42 minutes). Results. TOS and OSI values of whole patients at 30 minutes after reperfusion were higher than preoperative values (P = 0.045, P = 0.015), while perioperative TAS levels of the patients were similar to the preoperative levels (P = 0.173). XC time was correlated with TOS levels at 30 minutes after reperfusion (r = 0.43, P = 0.041). In group 2, TOS and OSI values at 30 minutes after reperfusion were higher than preoperative values (P = 0.023, P = 0.048), whereas a significant difference was not found in group 1 (P = 0.601, P = 0.327). Conclusions. Oxidative imbalance and increase in TOS at reperfusion in ONCABG may be associated with XC time. Hindawi Publishing Corporation 2014 2014-08-18 /pmc/articles/PMC4181498/ /pubmed/25302318 http://dx.doi.org/10.1155/2014/263058 Text en Copyright © 2014 Umit Mentese et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mentese, Umit Dogan, Orhan Veli Turan, Ibrahim Usta, Sefer Dogan, Emre Oztas Mentese, Seda Demir, Selim Ozer, Tanil Aykan, Ahmet Cagri Alver, Ahmet
spellingShingle	Mentese, Umit Dogan, Orhan Veli Turan, Ibrahim Usta, Sefer Dogan, Emre Oztas Mentese, Seda Demir, Selim Ozer, Tanil Aykan, Ahmet Cagri Alver, Ahmet Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting
author_facet	Mentese, Umit Dogan, Orhan Veli Turan, Ibrahim Usta, Sefer Dogan, Emre Oztas Mentese, Seda Demir, Selim Ozer, Tanil Aykan, Ahmet Cagri Alver, Ahmet
author_sort	Mentese, Umit
title	Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting
title_short	Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting
title_full	Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting
title_fullStr	Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting
title_full_unstemmed	Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting
title_sort	oxidant-antioxidant balance during on-pump coronary artery bypass grafting
description	Backround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG. Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed preoperatively, at 20 minutes after aortic clamping and at 30 minutes, 6 hours, and 48 hours after declamping (reperfusion). The patients were divided into 2 groups according to the median aortic cross clamping (XC) time: group 1 (XC time < 42 minutes) and group 2 (XC time ≥ 42 minutes). Results. TOS and OSI values of whole patients at 30 minutes after reperfusion were higher than preoperative values (P = 0.045, P = 0.015), while perioperative TAS levels of the patients were similar to the preoperative levels (P = 0.173). XC time was correlated with TOS levels at 30 minutes after reperfusion (r = 0.43, P = 0.041). In group 2, TOS and OSI values at 30 minutes after reperfusion were higher than preoperative values (P = 0.023, P = 0.048), whereas a significant difference was not found in group 1 (P = 0.601, P = 0.327). Conclusions. Oxidative imbalance and increase in TOS at reperfusion in ONCABG may be associated with XC time.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181498/
_version_	1613139544007245824

Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting

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