The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation
The control of chromosome segregation relies on the spindle assembly checkpoint (SAC), a complex regulatory system that ensures the high fidelity of chromosome segregation in higher organisms by delaying the onset of anaphase until each chromosome is properly bi-oriented on the mitotic spindle. Cent...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179342/ |
| id |
pubmed-4179342 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-41793422014-10-16 The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation Lee, Semin Bolanos-Garcia, Victor M. Physiology The control of chromosome segregation relies on the spindle assembly checkpoint (SAC), a complex regulatory system that ensures the high fidelity of chromosome segregation in higher organisms by delaying the onset of anaphase until each chromosome is properly bi-oriented on the mitotic spindle. Central to this process is the establishment of multiple yet specific protein-protein interactions in a narrow time-space window. Here we discuss the highly dynamic nature of multi-protein complexes that control chromosome segregation in which an intricate network of weak but cooperative interactions modulate signal amplification to ensure a proper SAC response. We also discuss the current structural understanding of the communication between the SAC and the kinetochore; how transient interactions can regulate the assembly and disassembly of the SAC as well as the challenges and opportunities for the definition and the manipulation of the flow of information in SAC signaling. Frontiers Media S.A. 2014-09-29 /pmc/articles/PMC4179342/ /pubmed/25324779 http://dx.doi.org/10.3389/fphys.2014.00368 Text en Copyright © 2014 Lee and Bolanos-Garcia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lee, Semin Bolanos-Garcia, Victor M. |
| spellingShingle |
Lee, Semin Bolanos-Garcia, Victor M. The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation |
| author_facet |
Lee, Semin Bolanos-Garcia, Victor M. |
| author_sort |
Lee, Semin |
| title |
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation |
| title_short |
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation |
| title_full |
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation |
| title_fullStr |
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation |
| title_full_unstemmed |
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation |
| title_sort |
dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation |
| description |
The control of chromosome segregation relies on the spindle assembly checkpoint (SAC), a complex regulatory system that ensures the high fidelity of chromosome segregation in higher organisms by delaying the onset of anaphase until each chromosome is properly bi-oriented on the mitotic spindle. Central to this process is the establishment of multiple yet specific protein-protein interactions in a narrow time-space window. Here we discuss the highly dynamic nature of multi-protein complexes that control chromosome segregation in which an intricate network of weak but cooperative interactions modulate signal amplification to ensure a proper SAC response. We also discuss the current structural understanding of the communication between the SAC and the kinetochore; how transient interactions can regulate the assembly and disassembly of the SAC as well as the challenges and opportunities for the definition and the manipulation of the flow of information in SAC signaling. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179342/ |
| _version_ |
1613138792428863488 |