Molecular imaging of plaques in coronary arteries with PET and SPECT

Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lumen stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not...

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Main Authors:	Sun, Zhong-Hua, Rashmizal, Hairil, Xu, Lei
Format:	Online
Language:	English
Published:	Science Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178519/

id	pubmed-4178519
recordtype	oai_dc
spelling	pubmed-41785192014-10-02 Molecular imaging of plaques in coronary arteries with PET and SPECT Sun, Zhong-Hua Rashmizal, Hairil Xu, Lei Review Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lumen stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increasingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of positron emission tomography (PET) and single photon emission computed tomography (SPECT) has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging techniques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coronary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed. Science Press 2014-09 /pmc/articles/PMC4178519/ /pubmed/25278976 http://dx.doi.org/10.11909/j.issn.1671-5411.2014.03.005 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sun, Zhong-Hua Rashmizal, Hairil Xu, Lei
spellingShingle	Sun, Zhong-Hua Rashmizal, Hairil Xu, Lei Molecular imaging of plaques in coronary arteries with PET and SPECT
author_facet	Sun, Zhong-Hua Rashmizal, Hairil Xu, Lei
author_sort	Sun, Zhong-Hua
title	Molecular imaging of plaques in coronary arteries with PET and SPECT
title_short	Molecular imaging of plaques in coronary arteries with PET and SPECT
title_full	Molecular imaging of plaques in coronary arteries with PET and SPECT
title_fullStr	Molecular imaging of plaques in coronary arteries with PET and SPECT
title_full_unstemmed	Molecular imaging of plaques in coronary arteries with PET and SPECT
title_sort	molecular imaging of plaques in coronary arteries with pet and spect
description	Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lumen stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increasingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of positron emission tomography (PET) and single photon emission computed tomography (SPECT) has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging techniques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coronary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed.
publisher	Science Press
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178519/
_version_	1613138570531307520

Molecular imaging of plaques in coronary arteries with PET and SPECT

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