Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report

Infections caused by carbapenem-resistant, Gram-negative bacteria are an increasing clinical challenge, since the antimicrobial treatment options are often limited to colistin methanesulfonate. No data are available regarding the pharmacokinetics of colistin in pleural fluid. We report the case of a...

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Main Authors:	Rana, Muhammad Asim, Rahman, Basheer Abd El, Mady, Ahmed Fouad, Odat, Mohammed Al, AlHarthy, Abdurehman, Ramadan, Omar El Sayed, Mumtaz, Shahzad Ahmed, Omrani, Ali S.
Format:	Online
Language:	English
Published:	PAGEPress Publications, Pavia, Italy 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178267/

id	pubmed-4178267
recordtype	oai_dc
spelling	pubmed-41782672014-09-30 Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report Rana, Muhammad Asim Rahman, Basheer Abd El Mady, Ahmed Fouad Odat, Mohammed Al AlHarthy, Abdurehman Ramadan, Omar El Sayed Mumtaz, Shahzad Ahmed Omrani, Ali S. Case Report Infections caused by carbapenem-resistant, Gram-negative bacteria are an increasing clinical challenge, since the antimicrobial treatment options are often limited to colistin methanesulfonate. No data are available regarding the pharmacokinetics of colistin in pleural fluid. We report the case of a 92-year old man with ventilator-associated pneumonia and pleurisy caused by Acinetobacter baumannii and Escherichia coli, which were both multidrug-resistant. After an unsuccessful treatment with intravenous colistin methanesulfonate and imipen-em-cilastatin, the addition of intra-pleural colistin methanesulfonate to the intravenous treatment led to a prompt clinical, radiological and microbiological resolution. This is the first report of a successful use of intra-pleural colistin in the literature. The intra-pleural colistin therapy should be considered in selected cases of pleurisy caused by multi-resistant Gram-negative bacteria. PAGEPress Publications, Pavia, Italy 2014-09-23 /pmc/articles/PMC4178267/ /pubmed/25276329 http://dx.doi.org/10.4081/idr.2014.5413 Text en ©Copyright M.A. Rana et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Rana, Muhammad Asim Rahman, Basheer Abd El Mady, Ahmed Fouad Odat, Mohammed Al AlHarthy, Abdurehman Ramadan, Omar El Sayed Mumtaz, Shahzad Ahmed Omrani, Ali S.
spellingShingle	Rana, Muhammad Asim Rahman, Basheer Abd El Mady, Ahmed Fouad Odat, Mohammed Al AlHarthy, Abdurehman Ramadan, Omar El Sayed Mumtaz, Shahzad Ahmed Omrani, Ali S. Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report
author_facet	Rana, Muhammad Asim Rahman, Basheer Abd El Mady, Ahmed Fouad Odat, Mohammed Al AlHarthy, Abdurehman Ramadan, Omar El Sayed Mumtaz, Shahzad Ahmed Omrani, Ali S.
author_sort	Rana, Muhammad Asim
title	Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report
title_short	Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report
title_full	Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report
title_fullStr	Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report
title_full_unstemmed	Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report
title_sort	intra-pleural colistin methanesulfonate therapy for pleural infection caused by carbapenem-resistant acinetobacter baumannii: a successful case report
description	Infections caused by carbapenem-resistant, Gram-negative bacteria are an increasing clinical challenge, since the antimicrobial treatment options are often limited to colistin methanesulfonate. No data are available regarding the pharmacokinetics of colistin in pleural fluid. We report the case of a 92-year old man with ventilator-associated pneumonia and pleurisy caused by Acinetobacter baumannii and Escherichia coli, which were both multidrug-resistant. After an unsuccessful treatment with intravenous colistin methanesulfonate and imipen-em-cilastatin, the addition of intra-pleural colistin methanesulfonate to the intravenous treatment led to a prompt clinical, radiological and microbiological resolution. This is the first report of a successful use of intra-pleural colistin in the literature. The intra-pleural colistin therapy should be considered in selected cases of pleurisy caused by multi-resistant Gram-negative bacteria.
publisher	PAGEPress Publications, Pavia, Italy
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178267/
_version_	1613138457055461376

Intra-Pleural Colistin Methanesulfonate Therapy for Pleural Infection caused by Carbapenem-Resistant Acinetobacter Baumannii: A Successful Case Report

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