Muscle Atrophy in Response to Cytotoxic Chemotherapy Is Dependent on Intact Glucocorticoid Signaling in Skeletal Muscle

Cancer cachexia is a syndrome of weight loss that results from the selective depletion of skeletal muscle mass and contributes significantly to cancer morbidity and mortality. The driver of skeletal muscle atrophy in cancer cachexia is systemic inflammation arising from both the cancer and cancer tr...

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Bibliographic Details
Main Authors: Braun, Theodore P., Szumowski, Marek, Levasseur, Peter R., Grossberg, Aaron J., Zhu, XinXia, Agarwal, Anupriya, Marks, Daniel L.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177815/