The functional role of long non-coding RNAs and epigenetics
Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the ep...
| Main Author: | |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177375/ |
| id |
pubmed-4177375 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-41773752014-09-29 The functional role of long non-coding RNAs and epigenetics Cao, Jinneng Review Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the epigenetic level, transcriptional and post-transcriptional level have been well known and widely studied. Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc. This review will focus on the functional roles of lncRNAs in epigenetics and related research progress will be summarized. BioMed Central 2014-09-15 /pmc/articles/PMC4177375/ /pubmed/25276098 http://dx.doi.org/10.1186/1480-9222-16-11 Text en Copyright © 2014 Cao; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cao, Jinneng |
| spellingShingle |
Cao, Jinneng The functional role of long non-coding RNAs and epigenetics |
| author_facet |
Cao, Jinneng |
| author_sort |
Cao, Jinneng |
| title |
The functional role of long non-coding RNAs and epigenetics |
| title_short |
The functional role of long non-coding RNAs and epigenetics |
| title_full |
The functional role of long non-coding RNAs and epigenetics |
| title_fullStr |
The functional role of long non-coding RNAs and epigenetics |
| title_full_unstemmed |
The functional role of long non-coding RNAs and epigenetics |
| title_sort |
functional role of long non-coding rnas and epigenetics |
| description |
Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the epigenetic level, transcriptional and post-transcriptional level have been well known and widely studied. Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc. This review will focus on the functional roles of lncRNAs in epigenetics and related research progress will be summarized. |
| publisher |
BioMed Central |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177375/ |
| _version_ |
1613138077978460160 |