Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancers have mismatch repair gene mutations and microsat...

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Bibliographic Details
Main Authors: Pritchard, Colin C., Morrissey, Colm, Kumar, Akash, Zhang, Xiaotun, Smith, Christina, Coleman, Ilsa, Salipante, Stephen J., Milbank, Jennifer, Yu, Ming, Grady, William M., Tait, Jonathan F., Corey, Eva, Vessella, Robert L., Walsh, Tom, Shendure, Jay, Nelson, Peter S.
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176888/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176888/

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