Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

Direct conversion of nonneural cells to functional neurons holds great promise for neurological disease modeling and regenerative medicine. We previously reported rapid reprogramming of mouse embryonic fibroblasts (MEFs) into mature induced neuronal (iN) cells by forced expression of three transcrip...

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Bibliographic Details
Main Authors: Chanda, Soham, Ang, Cheen Euong, Davila, Jonathan, Pak, ChangHui, Mall, Moritz, Lee, Qian Yi, Ahlenius, Henrik, Jung, Seung Woo, Südhof, Thomas C., Wernig, Marius
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176533/