Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability

Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability

R-loops, transcriptionally-induced RNA:DNA hybrids, occurring at repeat tracts (CTG)n, (CAG)n, (CGG)n, (CCG)n and (GAA)n, are associated with diseases including myotonic dystrophy, Huntington's disease, fragile X and Friedreich's ataxia. Many of these repeats are bidirectionally transcribe...

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Bibliographic Details
Main Authors: Reddy, Kaalak, Schmidt, Monika H.M., Geist, Jaimie M., Thakkar, Neha P., Panigrahi, Gagan B., Wang, Yuh-Hwa, Pearson, Christopher E.
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176329/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176329/

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