Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
The current concept of basal ganglia organization and function in physiological and pathophysiological conditions excludes the most numerous cells in the brain, i.e., the astrocytes, present with a ratio of 10:1 neuron. Their role in neurodegenerative condition such as Parkinson’s disease (PD) remai...
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| Format: | Online |
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Frontiers Media S.A.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174038/ |
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pubmed-41740382014-10-10 Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology? Charron, Giselle Doudnikoff, Evelyne Canron, Marie-Helene Li, Qin Véga, Céline Marais, Sebastien Baufreton, Jérôme Vital, Anne Oliet, Stéphane H. R. Bezard, Erwan Neuroscience The current concept of basal ganglia organization and function in physiological and pathophysiological conditions excludes the most numerous cells in the brain, i.e., the astrocytes, present with a ratio of 10:1 neuron. Their role in neurodegenerative condition such as Parkinson’s disease (PD) remains to be elucidated. Before embarking into physiological investigations of the yet-to-be-identified “tripartite” synapses in the basal ganglia in general and the striatum in particular, we therefore characterized anatomically the PD-related modifications in astrocytic morphology, the changes in astrocytic network connections and the consequences on the spatial relationship between astrocytic processes and asymmetric synapses in normal and PD-like conditions in experimental and human PD. Our results unravel a dramatic regulation of striatal astrocytosis supporting the hypothesis of a key role in (dys) regulating corticostriatal transmission. Astrocytes and their various properties might thus represent a therapeutic target in PD. Frontiers Media S.A. 2014-09-24 /pmc/articles/PMC4174038/ /pubmed/25309435 http://dx.doi.org/10.3389/fnagi.2014.00258 Text en Copyright © 2014 Charron, Doudnikoff, Canron, Li, Véga, Marais, Baufreton, Vital, Oliet and Bezard. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Charron, Giselle Doudnikoff, Evelyne Canron, Marie-Helene Li, Qin Véga, Céline Marais, Sebastien Baufreton, Jérôme Vital, Anne Oliet, Stéphane H. R. Bezard, Erwan |
| spellingShingle |
Charron, Giselle Doudnikoff, Evelyne Canron, Marie-Helene Li, Qin Véga, Céline Marais, Sebastien Baufreton, Jérôme Vital, Anne Oliet, Stéphane H. R. Bezard, Erwan Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology? |
| author_facet |
Charron, Giselle Doudnikoff, Evelyne Canron, Marie-Helene Li, Qin Véga, Céline Marais, Sebastien Baufreton, Jérôme Vital, Anne Oliet, Stéphane H. R. Bezard, Erwan |
| author_sort |
Charron, Giselle |
| title |
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology? |
| title_short |
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology? |
| title_full |
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology? |
| title_fullStr |
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology? |
| title_full_unstemmed |
Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology? |
| title_sort |
astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology? |
| description |
The current concept of basal ganglia organization and function in physiological and pathophysiological conditions excludes the most numerous cells in the brain, i.e., the astrocytes, present with a ratio of 10:1 neuron. Their role in neurodegenerative condition such as Parkinson’s disease (PD) remains to be elucidated. Before embarking into physiological investigations of the yet-to-be-identified “tripartite” synapses in the basal ganglia in general and the striatum in particular, we therefore characterized anatomically the PD-related modifications in astrocytic morphology, the changes in astrocytic network connections and the consequences on the spatial relationship between astrocytic processes and asymmetric synapses in normal and PD-like conditions in experimental and human PD. Our results unravel a dramatic regulation of striatal astrocytosis supporting the hypothesis of a key role in (dys) regulating corticostriatal transmission. Astrocytes and their various properties might thus represent a therapeutic target in PD. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174038/ |
| _version_ |
1613136967665451008 |