Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction

Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction

In humans infected with hepatitis B or C, high expression of a protein called T-bet in virus-fighting immune cells is associated with spontaneous clearance of the virus. Absence of T-bet was more often seen in patients whose infections became chronic.

Bibliographic Details
Main Authors: Kurktschiev, Peter D., Raziorrouh, Bijan, Schraut, Winfried, Backmund, Markus, Wächtler, Martin, Wendtner, Clemens-Martin, Bengsch, Bertram, Thimme, Robert, Denk, Gerald, Zachoval, Reinhart, Dick, Andrea, Spannagl, Michael, Haas, Jürgen, Diepolder, Helmut M., Jung, Maria-Christina, Gruener, Norbert H.
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172217/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172217/

Similar Items