Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Saturated free fatty acids (FFAs) have complex effects on the islet β-cell, acutely promoting adaptive hyperplasia but chronically impairing insulin release. The acute effects of FFAs remain incompletely defined. To elucidate these early molecular events, we incubated mouse β-cells and islets with p...

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Bibliographic Details
Main Authors: Hatanaka, Masayuki, Maier, Bernhard, Sims, Emily K., Templin, Andrew T., Kulkarni, Rohit N., Evans-Molina, Carmella, Mirmira, Raghavendra G.
Format: Online
Language:English
Published: American Diabetes Association 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171659/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171659/

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