Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma

Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma

Cisplatin can cause intrastrand and interstrand crosslinks between purine bases and is a chemotherapeutic drug widely used to treat cancer. However, the major barrier to the efficacy of the treatment is drug resistance. Homologous recombination (HR) plays a central role in restoring stalled forks ca...

Full description

Bibliographic Details
Main Authors: Su, Wen-Pin, Hsu, Sen-Huei, Wu, Cheng-Kuei, Chang, Song-Bin, Lin, Yi-Ju, Yang, Wen-Bin, Hung, Jan-Jong, Chiu, Wen-Tai, Tzeng, Shun-Fen, Tseng, Yau-Lin, Chang, Jang-Yang, Su, Wu-Chou, Liaw, Hungjiun
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171633/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171633/

Similar Items