Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses

Novel flaviviruses that are genetically related to pathogenic mosquito-borne flaviviruses (MBFV) have been isolated from mosquitoes in various geographical locations, including Finland. We isolated and characterized another novel virus of this group from Finnish mosquitoes collected in 2007, designa...

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Main Authors:	Huhtamo, Eili, Cook, Shelley, Moureau, Gregory, Uzcátegui, Nathalie Y., Sironen, Tarja, Kuivanen, Suvi, Putkuri, Niina, Kurkela, Satu, Harbach, Ralph E., Firth, Andrew E., Vapalahti, Olli, Gould, Ernest A., de Lamballerie, Xavier
Format:	Online
Language:	English
Published:	Academic Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170750/

id	pubmed-4170750
recordtype	oai_dc
spelling	pubmed-41707502014-09-23 Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses Huhtamo, Eili Cook, Shelley Moureau, Gregory Uzcátegui, Nathalie Y. Sironen, Tarja Kuivanen, Suvi Putkuri, Niina Kurkela, Satu Harbach, Ralph E. Firth, Andrew E. Vapalahti, Olli Gould, Ernest A. de Lamballerie, Xavier Article Novel flaviviruses that are genetically related to pathogenic mosquito-borne flaviviruses (MBFV) have been isolated from mosquitoes in various geographical locations, including Finland. We isolated and characterized another novel virus of this group from Finnish mosquitoes collected in 2007, designated as Ilomantsi virus (ILOV). Unlike the MBFV that infect both vertebrates and mosquitoes, the MBFV-related viruses appear to be specific to mosquitoes similar to the insect-specific flaviviruses (ISFs). In this overview of MBFV-related viruses we conclude that they differ from the ISFs genetically and antigenically. Phylogenetic analyses separated the MBFV-related viruses isolated in Africa, the Middle East and South America from those isolated in Europe and Asia. Serological cross-reactions of MBFV-related viruses with other flaviviruses and their potential for vector-borne transmission require further characterization. The divergent MBFV-related viruses are probably significantly under sampled to date and provide new information on the variety, properties and evolution of vector-borne flaviviruses. Academic Press 2014-09 /pmc/articles/PMC4170750/ /pubmed/25108382 http://dx.doi.org/10.1016/j.virol.2014.07.015 Text en © 2014 The Authors
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Huhtamo, Eili Cook, Shelley Moureau, Gregory Uzcátegui, Nathalie Y. Sironen, Tarja Kuivanen, Suvi Putkuri, Niina Kurkela, Satu Harbach, Ralph E. Firth, Andrew E. Vapalahti, Olli Gould, Ernest A. de Lamballerie, Xavier
spellingShingle	Huhtamo, Eili Cook, Shelley Moureau, Gregory Uzcátegui, Nathalie Y. Sironen, Tarja Kuivanen, Suvi Putkuri, Niina Kurkela, Satu Harbach, Ralph E. Firth, Andrew E. Vapalahti, Olli Gould, Ernest A. de Lamballerie, Xavier Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
author_facet	Huhtamo, Eili Cook, Shelley Moureau, Gregory Uzcátegui, Nathalie Y. Sironen, Tarja Kuivanen, Suvi Putkuri, Niina Kurkela, Satu Harbach, Ralph E. Firth, Andrew E. Vapalahti, Olli Gould, Ernest A. de Lamballerie, Xavier
author_sort	Huhtamo, Eili
title	Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
title_short	Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
title_full	Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
title_fullStr	Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
title_full_unstemmed	Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
title_sort	novel flaviviruses from mosquitoes: mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
description	Novel flaviviruses that are genetically related to pathogenic mosquito-borne flaviviruses (MBFV) have been isolated from mosquitoes in various geographical locations, including Finland. We isolated and characterized another novel virus of this group from Finnish mosquitoes collected in 2007, designated as Ilomantsi virus (ILOV). Unlike the MBFV that infect both vertebrates and mosquitoes, the MBFV-related viruses appear to be specific to mosquitoes similar to the insect-specific flaviviruses (ISFs). In this overview of MBFV-related viruses we conclude that they differ from the ISFs genetically and antigenically. Phylogenetic analyses separated the MBFV-related viruses isolated in Africa, the Middle East and South America from those isolated in Europe and Asia. Serological cross-reactions of MBFV-related viruses with other flaviviruses and their potential for vector-borne transmission require further characterization. The divergent MBFV-related viruses are probably significantly under sampled to date and provide new information on the variety, properties and evolution of vector-borne flaviviruses.
publisher	Academic Press
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170750/
_version_	1613135959279271936

Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses

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