Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors

Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors

A new series of compounds containing a sulfamide moiety as zinc-binding group (ZBG) has been synthesized and tested for determining inhibitory properties against four human carbonic anhydrase (hCA) isoforms, namely, CAs I, II, IX, and XII. The X-ray structure of the cytosolic dominant isoform hCA II...

Full description

Bibliographic Details
Main Authors: De Simone, Giuseppina, Pizika, Ginta, Monti, Simona Maria, Di Fiore, Anna, Ivanova, Jekaterina, Vozny, Igor, Trapencieris, Peteris, Zalubovskis, Raivis, Supuran, Claudiu T., Alterio, Vincenzo
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167230/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167230/

Similar Items