Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease

Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease

Amylin, a pancreatic peptide, and amyloid-beta peptides (Aβ), a major component of Alzheimer's disease (AD) brain, share similar β-sheet secondary structures, but it is not known whether pancreatic amylin affects amyloid pathogenesis in the AD brain. Using AD mouse models, we investigated the e...

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Bibliographic Details
Main Authors: Zhu, H, Wang, X, Wallack, M, Li, H, Carreras, I, Dedeoglu, A, Hur, J-Y, Zheng, H, Fine, R, Mwamburi, M, Sun, X, Kowall, N, Stern, R A, Qiu, W Q
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161670/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161670/

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