Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial

Recent studies suggest that antibiotic use could have an effect on growth in humans. Azithromycin is an antibiotic used for trachoma control, and hence, may have an unintended benefit of improving child growth. Niger is a trachoma-endemic country where mass antibiotic distributions for trachoma take...

Full description

Bibliographic Details
Main Authors:	Amza, Abdou, Yu, Sun N., Kadri, Boubacar, Nassirou, Baido, Stoller, Nicole E., Zhou, Zhaoxia, West, Sheila K., Bailey, Robin L., Gaynor, Bruce D., Keenan, Jeremy D., Porco, Travis C., Lietman, Thomas M.
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161345/

id	pubmed-4161345
recordtype	oai_dc
spelling	pubmed-41613452014-09-17 Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial Amza, Abdou Yu, Sun N. Kadri, Boubacar Nassirou, Baido Stoller, Nicole E. Zhou, Zhaoxia West, Sheila K. Bailey, Robin L. Gaynor, Bruce D. Keenan, Jeremy D. Porco, Travis C. Lietman, Thomas M. Research Article Recent studies suggest that antibiotic use could have an effect on growth in humans. Azithromycin is an antibiotic used for trachoma control, and hence, may have an unintended benefit of improving child growth. Niger is a trachoma-endemic country where mass antibiotic distributions for trachoma take place and where malnutrition is widespread among children. In addition, azithromycin may have an effect on common childhood diseases associated with malnutrition, such as diarrhea, pneumonia, and malaria. In a community-randomized trachoma trial in Matameye, Niger, we assessed child growth by measuring height, weight, and mid-upper arm circumference of pre-school children who have received 3 years of annual or biannual mass azithromycin treatment. While these measures were better in the biannually treated communities, the difference was not statistically significant. Thus, further research will help determine the impact of antibiotics on child growth and nutrition. Public Library of Science 2014-09-11 /pmc/articles/PMC4161345/ /pubmed/25210836 http://dx.doi.org/10.1371/journal.pntd.0003128 Text en © 2014 Amza et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Amza, Abdou Yu, Sun N. Kadri, Boubacar Nassirou, Baido Stoller, Nicole E. Zhou, Zhaoxia West, Sheila K. Bailey, Robin L. Gaynor, Bruce D. Keenan, Jeremy D. Porco, Travis C. Lietman, Thomas M.
spellingShingle	Amza, Abdou Yu, Sun N. Kadri, Boubacar Nassirou, Baido Stoller, Nicole E. Zhou, Zhaoxia West, Sheila K. Bailey, Robin L. Gaynor, Bruce D. Keenan, Jeremy D. Porco, Travis C. Lietman, Thomas M. Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial
author_facet	Amza, Abdou Yu, Sun N. Kadri, Boubacar Nassirou, Baido Stoller, Nicole E. Zhou, Zhaoxia West, Sheila K. Bailey, Robin L. Gaynor, Bruce D. Keenan, Jeremy D. Porco, Travis C. Lietman, Thomas M.
author_sort	Amza, Abdou
title	Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial
title_short	Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial
title_full	Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial
title_fullStr	Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial
title_full_unstemmed	Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial
title_sort	does mass azithromycin distribution impact child growth and nutrition in niger? a cluster-randomized trial
description	Recent studies suggest that antibiotic use could have an effect on growth in humans. Azithromycin is an antibiotic used for trachoma control, and hence, may have an unintended benefit of improving child growth. Niger is a trachoma-endemic country where mass antibiotic distributions for trachoma take place and where malnutrition is widespread among children. In addition, azithromycin may have an effect on common childhood diseases associated with malnutrition, such as diarrhea, pneumonia, and malaria. In a community-randomized trachoma trial in Matameye, Niger, we assessed child growth by measuring height, weight, and mid-upper arm circumference of pre-school children who have received 3 years of annual or biannual mass azithromycin treatment. While these measures were better in the biannually treated communities, the difference was not statistically significant. Thus, further research will help determine the impact of antibiotics on child growth and nutrition.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161345/
_version_	1613133088351584256

Does Mass Azithromycin Distribution Impact Child Growth and Nutrition in Niger? A Cluster-Randomized Trial

Similar Items