Mechanisms Underlying the Exquisite Sensitivity of Candida albicans to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes

Mechanisms Underlying the Exquisite Sensitivity of Candida albicans to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes

Immune cells exploit reactive oxygen species (ROS) and cationic fluxes to kill microbial pathogens, such as the fungus Candida albicans. Yet, C. albicans is resistant to these stresses in vitro. Therefore, what accounts for the potent antifungal activity of neutrophils? We show that simultaneous exp...

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Bibliographic Details
Main Authors: Kaloriti, Despoina, Jacobsen, Mette, Yin, Zhikang, Patterson, Miranda, Tillmann, Anna, Smith, Deborah A., Cook, Emily, You, Tao, Grimm, Melissa J., Bohovych, Iryna, Grebogi, Celso, Segal, Brahm H., Gow, Neil A. R., Haynes, Ken, Quinn, Janet, Brown, Alistair J. P.
Format: Online
Language:English
Published: American Society of Microbiology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161263/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161263/

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