Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare

Campylobacter jejuni is the leading cause of bacterial food-borne infection; chicken meat is its main source. C. jejuni is considered commensal in chickens based on experimental models unrepresentative of commercial production. Here we show that the paradigm of Campylobacter commensalism in the chic...

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Main Authors:	Humphrey, Suzanne, Chaloner, Gemma, Kemmett, Kirsty, Davidson, Nicola, Williams, Nicola, Kipar, Anja, Humphrey, Tom, Wigley, Paul
Format:	Online
Language:	English
Published:	American Society of Microbiology 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161246/

id	pubmed-4161246
recordtype	oai_dc
spelling	pubmed-41612462014-09-11 Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare Humphrey, Suzanne Chaloner, Gemma Kemmett, Kirsty Davidson, Nicola Williams, Nicola Kipar, Anja Humphrey, Tom Wigley, Paul Research Article Campylobacter jejuni is the leading cause of bacterial food-borne infection; chicken meat is its main source. C. jejuni is considered commensal in chickens based on experimental models unrepresentative of commercial production. Here we show that the paradigm of Campylobacter commensalism in the chicken is flawed. Through experimental infection of four commercial breeds of broiler chickens, we show that breed has a significant effect on C. jejuni infection and the immune response of the animals, although these factors have limited impact on the number of bacteria in chicken ceca. All breeds mounted an innate immune response. In some breeds, this response declined when interleukin-10 was expressed, consistent with regulation of the intestinal inflammatory response, and these birds remained healthy. In another breed, there was a prolonged inflammatory response, evidence of damage to gut mucosa, and diarrhea. We show that bird type has a major impact on infection biology of C. jejuni. In some breeds, infection leads to disease, and the bacterium cannot be considered a harmless commensal. These findings have implications for the welfare of chickens in commercial production where C. jejuni infection is a persistent problem. American Society of Microbiology 2014-07-01 /pmc/articles/PMC4161246/ /pubmed/24987092 http://dx.doi.org/10.1128/mBio.01364-14 Text en Copyright © 2014 Humphrey et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Humphrey, Suzanne Chaloner, Gemma Kemmett, Kirsty Davidson, Nicola Williams, Nicola Kipar, Anja Humphrey, Tom Wigley, Paul
spellingShingle	Humphrey, Suzanne Chaloner, Gemma Kemmett, Kirsty Davidson, Nicola Williams, Nicola Kipar, Anja Humphrey, Tom Wigley, Paul Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare
author_facet	Humphrey, Suzanne Chaloner, Gemma Kemmett, Kirsty Davidson, Nicola Williams, Nicola Kipar, Anja Humphrey, Tom Wigley, Paul
author_sort	Humphrey, Suzanne
title	Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare
title_short	Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare
title_full	Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare
title_fullStr	Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare
title_full_unstemmed	Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare
title_sort	campylobacter jejuni is not merely a commensal in commercial broiler chickens and affects bird welfare
description	Campylobacter jejuni is the leading cause of bacterial food-borne infection; chicken meat is its main source. C. jejuni is considered commensal in chickens based on experimental models unrepresentative of commercial production. Here we show that the paradigm of Campylobacter commensalism in the chicken is flawed. Through experimental infection of four commercial breeds of broiler chickens, we show that breed has a significant effect on C. jejuni infection and the immune response of the animals, although these factors have limited impact on the number of bacteria in chicken ceca. All breeds mounted an innate immune response. In some breeds, this response declined when interleukin-10 was expressed, consistent with regulation of the intestinal inflammatory response, and these birds remained healthy. In another breed, there was a prolonged inflammatory response, evidence of damage to gut mucosa, and diarrhea. We show that bird type has a major impact on infection biology of C. jejuni. In some breeds, infection leads to disease, and the bacterium cannot be considered a harmless commensal. These findings have implications for the welfare of chickens in commercial production where C. jejuni infection is a persistent problem.
publisher	American Society of Microbiology
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161246/
_version_	1613133040459972608

Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare

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