Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats
Tongxinluo has been widely used in China for the treatment of acute stroke and for neuroprotection. However, there are few positron emission tomography (PET) studies on the neuroprotective effect of Tongxinluo on cerebral ischemia/reperfusion in small animals. In the present study, Tongxinluo superf...
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Medknow Publications & Media Pvt Ltd
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160852/ |
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pubmed-41608522014-09-14 Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats Cheng, Xiao Luo, Haoxuan Zhou, Lihua Wang, Lixin Sun, Jingbo Huang, Yan Luo, Enli Cai, Yefeng Research and Report Tongxinluo has been widely used in China for the treatment of acute stroke and for neuroprotection. However, there are few positron emission tomography (PET) studies on the neuroprotective effect of Tongxinluo on cerebral ischemia/reperfusion in small animals. In the present study, Tongxinluo superfine powder suspension or its vehicle was administered intragastrically to rats for 5 successive days before middle cerebral artery occlusion. 18F-fluorodeoxyglucose (FDG) small animal PET imaging showed that at 1 and 2 weeks after cerebral ischemia/reperfusion, glucose metabolism in the ischemic area was greater in rats that had received Tongxinluo than in those that had received the vehicle. Nissl staining showed that 2 weeks after cerebral ischemia/reperfusion, there was less neuronal loss in the prefrontal cortex in Tongxinluo-treated rats than in controls. In addition, Tongxinluo-treated animals showed better neurologic function and lower cerebral infarct volume than rats that received the vehicle. These findings suggest that Tongxinluo exhibits neuroprotective effects in cerebral ischemia/reperfusion injury and demonstrates that 18F-FDG small animal PET imaging is a useful tool with which to study the molecular pharmacology of traditional Chinese medicine. Medknow Publications & Media Pvt Ltd 2014-07-01 /pmc/articles/PMC4160852/ /pubmed/25221578 http://dx.doi.org/10.4103/1673-5374.137573 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cheng, Xiao Luo, Haoxuan Zhou, Lihua Wang, Lixin Sun, Jingbo Huang, Yan Luo, Enli Cai, Yefeng |
| spellingShingle |
Cheng, Xiao Luo, Haoxuan Zhou, Lihua Wang, Lixin Sun, Jingbo Huang, Yan Luo, Enli Cai, Yefeng Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats |
| author_facet |
Cheng, Xiao Luo, Haoxuan Zhou, Lihua Wang, Lixin Sun, Jingbo Huang, Yan Luo, Enli Cai, Yefeng |
| author_sort |
Cheng, Xiao |
| title |
Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats |
| title_short |
Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats |
| title_full |
Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats |
| title_fullStr |
Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats |
| title_full_unstemmed |
Neuroprotective effect of the traditional Chinese herbal formula Tongxinluo: a PET imaging study in rats |
| title_sort |
neuroprotective effect of the traditional chinese herbal formula tongxinluo: a pet imaging study in rats |
| description |
Tongxinluo has been widely used in China for the treatment of acute stroke and for neuroprotection. However, there are few positron emission tomography (PET) studies on the neuroprotective effect of Tongxinluo on cerebral ischemia/reperfusion in small animals. In the present study, Tongxinluo superfine powder suspension or its vehicle was administered intragastrically to rats for 5 successive days before middle cerebral artery occlusion. 18F-fluorodeoxyglucose (FDG) small animal PET imaging showed that at 1 and 2 weeks after cerebral ischemia/reperfusion, glucose metabolism in the ischemic area was greater in rats that had received Tongxinluo than in those that had received the vehicle. Nissl staining showed that 2 weeks after cerebral ischemia/reperfusion, there was less neuronal loss in the prefrontal cortex in Tongxinluo-treated rats than in controls. In addition, Tongxinluo-treated animals showed better neurologic function and lower cerebral infarct volume than rats that received the vehicle. These findings suggest that Tongxinluo exhibits neuroprotective effects in cerebral ischemia/reperfusion injury and demonstrates that 18F-FDG small animal PET imaging is a useful tool with which to study the molecular pharmacology of traditional Chinese medicine. |
| publisher |
Medknow Publications & Media Pvt Ltd |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160852/ |
| _version_ |
1613132929781727232 |