Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa
Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy. Until now, the exact pathogenesis and etiology of this disease has not been clear, and many approaches for RP therapies hav...
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| Format: | Online |
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MDPI
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159862/ |
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pubmed-41598622014-09-18 Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa He, Yuxi Zhang, Yan Liu, Xin Ghazaryan, Emma Li, Ying Xie, Jianan Su, Guanfang Review Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy. Until now, the exact pathogenesis and etiology of this disease has not been clear, and many approaches for RP therapies have been carried out in animals and in clinical trials. In recent years, stem cell transplantation-based attempts made some progress, especially the transplantation of bone marrow-derived mesenchymal stem cells (BMSCs). This review will provide an overview of stem cell-based treatment of RP and its main problems, to provide evidence for the safety and feasibility for further clinical treatment. MDPI 2014-08-20 /pmc/articles/PMC4159862/ /pubmed/25141102 http://dx.doi.org/10.3390/ijms150814456 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
He, Yuxi Zhang, Yan Liu, Xin Ghazaryan, Emma Li, Ying Xie, Jianan Su, Guanfang |
| spellingShingle |
He, Yuxi Zhang, Yan Liu, Xin Ghazaryan, Emma Li, Ying Xie, Jianan Su, Guanfang Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa |
| author_facet |
He, Yuxi Zhang, Yan Liu, Xin Ghazaryan, Emma Li, Ying Xie, Jianan Su, Guanfang |
| author_sort |
He, Yuxi |
| title |
Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa |
| title_short |
Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa |
| title_full |
Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa |
| title_fullStr |
Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa |
| title_full_unstemmed |
Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa |
| title_sort |
recent advances of stem cell therapy for retinitis pigmentosa |
| description |
Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy. Until now, the exact pathogenesis and etiology of this disease has not been clear, and many approaches for RP therapies have been carried out in animals and in clinical trials. In recent years, stem cell transplantation-based attempts made some progress, especially the transplantation of bone marrow-derived mesenchymal stem cells (BMSCs). This review will provide an overview of stem cell-based treatment of RP and its main problems, to provide evidence for the safety and feasibility for further clinical treatment. |
| publisher |
MDPI |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159862/ |
| _version_ |
1613132641423327232 |