Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication

Rapid divergence of gene copies after duplication is thought to determine the fate of the copies and evolution of novel protein functions. However, data on how long the gene copies continue to experience an elevated rate of evolution remain scarce. Standard theory of gene duplications based on some...

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Main Authors:	Pich i Roselló, Oriol, Kondrashov, Fyodor A.
Format:	Online
Language:	English
Published:	Oxford University Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159008/

id	pubmed-4159008
recordtype	oai_dc
spelling	pubmed-41590082014-09-10 Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication Pich i Roselló, Oriol Kondrashov, Fyodor A. Research Article Rapid divergence of gene copies after duplication is thought to determine the fate of the copies and evolution of novel protein functions. However, data on how long the gene copies continue to experience an elevated rate of evolution remain scarce. Standard theory of gene duplications based on some level of genetic redundancy of gene copies predicts that the period of accelerated evolution must end relatively quickly. Using a maximum-likelihood approach we estimate preduplication, initial postduplication, and recent postduplication rates of evolution that occurred in the mammalian lineage. We find that both gene copies experience a similar in magnitude acceleration in their rate of evolution. The copy located in the original genomic position typically returns to the preduplication rates of evolution in a short period of time. The burst of faster evolution of the copy that is located in a new genomic position typically lasts longer. Furthermore, the fast-evolving copies on average continue to evolve faster than the preduplication rates far longer than predicted by standard theory of gene duplications. We hypothesize that the prolonged elevated rates of evolution are determined by functional properties that were acquired during, or soon after, the gene duplication event. Oxford University Press 2014-07-28 /pmc/articles/PMC4159008/ /pubmed/25070510 http://dx.doi.org/10.1093/gbe/evu159 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pich i Roselló, Oriol Kondrashov, Fyodor A.
spellingShingle	Pich i Roselló, Oriol Kondrashov, Fyodor A. Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication
author_facet	Pich i Roselló, Oriol Kondrashov, Fyodor A.
author_sort	Pich i Roselló, Oriol
title	Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication
title_short	Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication
title_full	Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication
title_fullStr	Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication
title_full_unstemmed	Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication
title_sort	long-term asymmetrical acceleration of protein evolution after gene duplication
description	Rapid divergence of gene copies after duplication is thought to determine the fate of the copies and evolution of novel protein functions. However, data on how long the gene copies continue to experience an elevated rate of evolution remain scarce. Standard theory of gene duplications based on some level of genetic redundancy of gene copies predicts that the period of accelerated evolution must end relatively quickly. Using a maximum-likelihood approach we estimate preduplication, initial postduplication, and recent postduplication rates of evolution that occurred in the mammalian lineage. We find that both gene copies experience a similar in magnitude acceleration in their rate of evolution. The copy located in the original genomic position typically returns to the preduplication rates of evolution in a short period of time. The burst of faster evolution of the copy that is located in a new genomic position typically lasts longer. Furthermore, the fast-evolving copies on average continue to evolve faster than the preduplication rates far longer than predicted by standard theory of gene duplications. We hypothesize that the prolonged elevated rates of evolution are determined by functional properties that were acquired during, or soon after, the gene duplication event.
publisher	Oxford University Press
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159008/
_version_	1613132358057197568

Long-Term Asymmetrical Acceleration of Protein Evolution after Gene Duplication

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