Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature

Squamous cell carcinoma is a common malignant tumor of the uterine cervix. The present study reports the case of squamous cell carcinoma of the uterine cervix with osteoclast-like giant cells (OGCs) in an 84-year-old female who had suffered from irregular vaginal bleeding for one month. Colposcopy w...

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Main Authors:	YU, GUOHUA, LIN, CHUNHUA, WANG, WEI, HAN, YEKUN, QU, GUIMEI, ZHANG, TINGGUO
Format:	Online
Language:	English
Published:	D.A. Spandidos 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156229/

id	pubmed-4156229
recordtype	oai_dc
spelling	pubmed-41562292014-09-08 Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature YU, GUOHUA LIN, CHUNHUA WANG, WEI HAN, YEKUN QU, GUIMEI ZHANG, TINGGUO Articles Squamous cell carcinoma is a common malignant tumor of the uterine cervix. The present study reports the case of squamous cell carcinoma of the uterine cervix with osteoclast-like giant cells (OGCs) in an 84-year-old female who had suffered from irregular vaginal bleeding for one month. Colposcopy was performed and a cauliflower-like mass was identified in the front lip of the uterine cervix. Biopsy was then performed, and the tumor was found to be composed of epithelial cell nests, ranging in size. The neoplastic cells exhibited unclear boundaries and eosinophilic cytoplasm. Additionally, the nuclei were atypical and mitosis was observed. Among the epithelial nests, there were numerous OGCs with abundant eosinophilic cytoplasm, as well as multinucleation with bland nuclei. By immunohistochemical staining, the epithelial cells were positive for cytokeratin, while negative for CD68 and vimentin. By contrast, the immunophenotype of the OGCs was the exact opposite. Based on the histological characters, a diagnosis of squamous cell carcinoma of the uterine cervix associated with OGCs was made. Considering the age of the patient, radiotherapy was administered. The patient succumbed to brain metastasis of the tumor after eight months of follow-up. D.A. Spandidos 2014-10 2014-07-25 /pmc/articles/PMC4156229/ /pubmed/25202374 http://dx.doi.org/10.3892/ol.2014.2384 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	YU, GUOHUA LIN, CHUNHUA WANG, WEI HAN, YEKUN QU, GUIMEI ZHANG, TINGGUO
spellingShingle	YU, GUOHUA LIN, CHUNHUA WANG, WEI HAN, YEKUN QU, GUIMEI ZHANG, TINGGUO Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature
author_facet	YU, GUOHUA LIN, CHUNHUA WANG, WEI HAN, YEKUN QU, GUIMEI ZHANG, TINGGUO
author_sort	YU, GUOHUA
title	Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature
title_short	Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature
title_full	Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature
title_fullStr	Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature
title_full_unstemmed	Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature
title_sort	squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: a case report and review of the literature
description	Squamous cell carcinoma is a common malignant tumor of the uterine cervix. The present study reports the case of squamous cell carcinoma of the uterine cervix with osteoclast-like giant cells (OGCs) in an 84-year-old female who had suffered from irregular vaginal bleeding for one month. Colposcopy was performed and a cauliflower-like mass was identified in the front lip of the uterine cervix. Biopsy was then performed, and the tumor was found to be composed of epithelial cell nests, ranging in size. The neoplastic cells exhibited unclear boundaries and eosinophilic cytoplasm. Additionally, the nuclei were atypical and mitosis was observed. Among the epithelial nests, there were numerous OGCs with abundant eosinophilic cytoplasm, as well as multinucleation with bland nuclei. By immunohistochemical staining, the epithelial cells were positive for cytokeratin, while negative for CD68 and vimentin. By contrast, the immunophenotype of the OGCs was the exact opposite. Based on the histological characters, a diagnosis of squamous cell carcinoma of the uterine cervix associated with OGCs was made. Considering the age of the patient, radiotherapy was administered. The patient succumbed to brain metastasis of the tumor after eight months of follow-up.
publisher	D.A. Spandidos
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156229/
_version_	1613131480539594752

Squamous cell carcinoma of the uterine cervix associated with osteoclast-like giant cells: A case report and review of the literature

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