Controlled Human Malaria Infection of Tanzanians by Intradermal Injection of Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites

Controlled human malaria infection (CHMI) by mosquito bite has been used to assess anti-malaria interventions in > 1,500 volunteers since development of methods for infecting mosquitoes by feeding on Plasmodium falciparum (Pf) gametocyte cultures. Such CHMIs have never been used in Africa. Asepti...

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Main Authors: Shekalaghe, Seif, Rutaihwa, Mastidia, Billingsley, Peter F., Chemba, Mwajuma, Daubenberger, Claudia A., James, Eric R., Mpina, Maximillian, Ali Juma, Omar, Schindler, Tobias, Huber, Eric, Gunasekera, Anusha, Manoj, Anita, Simon, Beatus, Saverino, Elizabeth, Church, L. W. Preston, Hermsen, Cornelus C., Sauerwein, Robert W., Plowe, Christopher, Venkatesan, Meera, Sasi, Philip, Lweno, Omar, Mutani, Paul, Hamad, Ali, Mohammed, Ali, Urassa, Alwisa, Mzee, Tutu, Padilla, Debbie, Ruben, Adam, Lee Sim, B. Kim, Tanner, Marcel, Abdulla, Salim, Hoffman, Stephen L.
Format: Online
Language:English
Published: The American Society of Tropical Medicine and Hygiene 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155546/