Tracing the Evolution of the p53 Tetramerization Domain
The tetrameric transcription factors p53, p63, and p73 evolved from a common ancestor and play key roles in tumor suppression and development. Surprisingly, p63 and p73 require a second helix in their tetramerization domain for the formation of stable tetramers that is absent in human p53, raising q...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155161/ |