Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation

Maternal inflammation during pregnancy is associated with the later development of cognitive and behavioral impairment in the offspring, reminiscent of the traits of schizophrenia or autism spectrum disorders. Hippocampal long-term potentiation and long-term depression of glutamatergic synapses are...

Full description

Bibliographic Details
Main Authors:	Rideau Batista Novais, Aline, Crouzin, Nadine, Cavalier, Mélanie, Boubal, Mathilde, Guiramand, Janique, Cohen-Solal, Catherine, de Jesus Ferreira, Marie-Céleste, Cambonie, Gilles, Vignes, Michel, Barbanel, Gérard
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153642/

id	pubmed-4153642
recordtype	oai_dc
spelling	pubmed-41536422014-09-05 Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation Rideau Batista Novais, Aline Crouzin, Nadine Cavalier, Mélanie Boubal, Mathilde Guiramand, Janique Cohen-Solal, Catherine de Jesus Ferreira, Marie-Céleste Cambonie, Gilles Vignes, Michel Barbanel, Gérard Research Article Maternal inflammation during pregnancy is associated with the later development of cognitive and behavioral impairment in the offspring, reminiscent of the traits of schizophrenia or autism spectrum disorders. Hippocampal long-term potentiation and long-term depression of glutamatergic synapses are respectively involved in memory formation and consolidation. In male rats, maternal inflammation with lipopolysaccharide (LPS) led to a premature loss of long-term depression, occurring between 12 and 25 postnatal days instead of after the first postnatal month, and aberrant occurrence of long-term potentiation. We hypothesized this would be related to GABAergic system impairment. Sprague Dawley rats received either LPS or isotonic saline ip on gestational day 19. Male offspring's hippocampus was studied between 12 and 25 postnatal days. Morphological and functional analyses demonstrated that prenatal LPS triggered a deficit of hippocampal GABAergic interneurons, associated with presynaptic GABAergic transmission deficiency in male offspring. Increasing ambient GABA by impairing GABA reuptake with tiagabine did not interact with the low frequency-induced long-term depression in control animals but fully prevented its impairment in male offspring of LPS-challenged dams. Tiagabine furthermore prevented the aberrant occurrence of paired-pulse triggered long-term potentiation in these rats. Deficiency in GABA seems to be central to the dysregulation of synaptic plasticity observed in juvenile in utero LPS-challenged rats. Modulating GABAergic tone may be a possible therapeutic strategy at this developmental stage. Public Library of Science 2014-09-03 /pmc/articles/PMC4153642/ /pubmed/25184226 http://dx.doi.org/10.1371/journal.pone.0106302 Text en © 2014 Rideau Batista Novais et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Rideau Batista Novais, Aline Crouzin, Nadine Cavalier, Mélanie Boubal, Mathilde Guiramand, Janique Cohen-Solal, Catherine de Jesus Ferreira, Marie-Céleste Cambonie, Gilles Vignes, Michel Barbanel, Gérard
spellingShingle	Rideau Batista Novais, Aline Crouzin, Nadine Cavalier, Mélanie Boubal, Mathilde Guiramand, Janique Cohen-Solal, Catherine de Jesus Ferreira, Marie-Céleste Cambonie, Gilles Vignes, Michel Barbanel, Gérard Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation
author_facet	Rideau Batista Novais, Aline Crouzin, Nadine Cavalier, Mélanie Boubal, Mathilde Guiramand, Janique Cohen-Solal, Catherine de Jesus Ferreira, Marie-Céleste Cambonie, Gilles Vignes, Michel Barbanel, Gérard
author_sort	Rideau Batista Novais, Aline
title	Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation
title_short	Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation
title_full	Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation
title_fullStr	Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation
title_full_unstemmed	Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation
title_sort	tiagabine improves hippocampal long-term depression in rat pups subjected to prenatal inflammation
description	Maternal inflammation during pregnancy is associated with the later development of cognitive and behavioral impairment in the offspring, reminiscent of the traits of schizophrenia or autism spectrum disorders. Hippocampal long-term potentiation and long-term depression of glutamatergic synapses are respectively involved in memory formation and consolidation. In male rats, maternal inflammation with lipopolysaccharide (LPS) led to a premature loss of long-term depression, occurring between 12 and 25 postnatal days instead of after the first postnatal month, and aberrant occurrence of long-term potentiation. We hypothesized this would be related to GABAergic system impairment. Sprague Dawley rats received either LPS or isotonic saline ip on gestational day 19. Male offspring's hippocampus was studied between 12 and 25 postnatal days. Morphological and functional analyses demonstrated that prenatal LPS triggered a deficit of hippocampal GABAergic interneurons, associated with presynaptic GABAergic transmission deficiency in male offspring. Increasing ambient GABA by impairing GABA reuptake with tiagabine did not interact with the low frequency-induced long-term depression in control animals but fully prevented its impairment in male offspring of LPS-challenged dams. Tiagabine furthermore prevented the aberrant occurrence of paired-pulse triggered long-term potentiation in these rats. Deficiency in GABA seems to be central to the dysregulation of synaptic plasticity observed in juvenile in utero LPS-challenged rats. Modulating GABAergic tone may be a possible therapeutic strategy at this developmental stage.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153642/
_version_	1613130688365592576

Tiagabine Improves Hippocampal Long-Term Depression in Rat Pups Subjected to Prenatal Inflammation

Similar Items