Nanostructure-based platforms-current prospective in ophthalmic drug delivery
The topically applied drugs as drops are washed off from the eye in very short period, resulting in low ocular bioavailability of drugs. Number of approaches have been attempted to increase the bioavailability and the duration of action of ocular drugs. This review provides an insight into various n...
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| Format: | Online |
| Language: | English |
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Medknow Publications & Media Pvt Ltd
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152643/ |
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pubmed-41526432014-09-04 Nanostructure-based platforms-current prospective in ophthalmic drug delivery Sharma, Rakesh Kumar Yassin, Alaa Eldeen B Review Article The topically applied drugs as drops are washed off from the eye in very short period, resulting in low ocular bioavailability of drugs. Number of approaches have been attempted to increase the bioavailability and the duration of action of ocular drugs. This review provides an insight into various novel approaches; hydrophilic nanogels, solid lipid nanoparticles, and nanosponges applied very recently in the delivery of insoluble drugs, prolonging the ocular residence time, minimize pre-corneal drug loss and, therefore, bioavailability and therapeutic efficacy of the drugs. Despite various scientific approaches, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. Medknow Publications & Media Pvt Ltd 2014-07 /pmc/articles/PMC4152643/ /pubmed/25116766 http://dx.doi.org/10.4103/0301-4738.138301 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sharma, Rakesh Kumar Yassin, Alaa Eldeen B |
| spellingShingle |
Sharma, Rakesh Kumar Yassin, Alaa Eldeen B Nanostructure-based platforms-current prospective in ophthalmic drug delivery |
| author_facet |
Sharma, Rakesh Kumar Yassin, Alaa Eldeen B |
| author_sort |
Sharma, Rakesh Kumar |
| title |
Nanostructure-based platforms-current prospective in ophthalmic drug delivery |
| title_short |
Nanostructure-based platforms-current prospective in ophthalmic drug delivery |
| title_full |
Nanostructure-based platforms-current prospective in ophthalmic drug delivery |
| title_fullStr |
Nanostructure-based platforms-current prospective in ophthalmic drug delivery |
| title_full_unstemmed |
Nanostructure-based platforms-current prospective in ophthalmic drug delivery |
| title_sort |
nanostructure-based platforms-current prospective in ophthalmic drug delivery |
| description |
The topically applied drugs as drops are washed off from the eye in very short period, resulting in low ocular bioavailability of drugs. Number of approaches have been attempted to increase the bioavailability and the duration of action of ocular drugs. This review provides an insight into various novel approaches; hydrophilic nanogels, solid lipid nanoparticles, and nanosponges applied very recently in the delivery of insoluble drugs, prolonging the ocular residence time, minimize pre-corneal drug loss and, therefore, bioavailability and therapeutic efficacy of the drugs. Despite various scientific approaches, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. |
| publisher |
Medknow Publications & Media Pvt Ltd |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152643/ |
| _version_ |
1613130333773889536 |