Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats

Physical exercise has been proved to be neuroprotective in clinical trials and animal experiments. However, the exact mechanism underlying this neuroprotective effect remains unclear. The aim of the present study was to explore whether pre-ischemic treadmill training could act as a form of ischemic...

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Main Authors:	FENG, RUI, ZHANG, MIN, WANG, XIAO, LI, WEN-BIN, REN, SHI-QING, ZHANG, FENG
Format:	Online
Language:	English
Published:	D.A. Spandidos 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151673/

id	pubmed-4151673
recordtype	oai_dc
spelling	pubmed-41516732014-09-03 Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats FENG, RUI ZHANG, MIN WANG, XIAO LI, WEN-BIN REN, SHI-QING ZHANG, FENG Articles Physical exercise has been proved to be neuroprotective in clinical trials and animal experiments. However, the exact mechanism underlying this neuroprotective effect remains unclear. The aim of the present study was to explore whether pre-ischemic treadmill training could act as a form of ischemic preconditioning in a rat following ischemic stroke by reducing oxidative damage. Fifty-four rats were randomly divided into three groups (n=18 per group): Sham surgery, middle cerebral artery occlusion (MCAO) without exercise and MCAO with exercise. Subsequent to treadmill training, ischemic stroke was induced by occluding the MCA for 1.5 h, followed by reperfusion. Six rats in each group were evaluated for neurological deficits and then sacrificed by decapitation to calculate the infarct volume. The remaining rats in each group were sacrificed to detect the level of superoxide dismutase (SOD) activity (n=6) and malondialdehyde (MDA) concentration (n=6). The results indicated that pre-ischemic exercise training reduced brain infarct volume and neurological deficits, increased SOD activity and decreased the concentration of MDA following ischemic stroke. In conclusion, treadmill exercise training prior to MCAO/reperfusion increased the antioxidant ability and decreased the oxidative damage in the brain subsequent to ischemic stroke. D.A. Spandidos 2014-10 2014-07-31 /pmc/articles/PMC4151673/ /pubmed/25187848 http://dx.doi.org/10.3892/etm.2014.1874 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	FENG, RUI ZHANG, MIN WANG, XIAO LI, WEN-BIN REN, SHI-QING ZHANG, FENG
spellingShingle	FENG, RUI ZHANG, MIN WANG, XIAO LI, WEN-BIN REN, SHI-QING ZHANG, FENG Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats
author_facet	FENG, RUI ZHANG, MIN WANG, XIAO LI, WEN-BIN REN, SHI-QING ZHANG, FENG
author_sort	FENG, RUI
title	Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats
title_short	Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats
title_full	Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats
title_fullStr	Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats
title_full_unstemmed	Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats
title_sort	pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats
description	Physical exercise has been proved to be neuroprotective in clinical trials and animal experiments. However, the exact mechanism underlying this neuroprotective effect remains unclear. The aim of the present study was to explore whether pre-ischemic treadmill training could act as a form of ischemic preconditioning in a rat following ischemic stroke by reducing oxidative damage. Fifty-four rats were randomly divided into three groups (n=18 per group): Sham surgery, middle cerebral artery occlusion (MCAO) without exercise and MCAO with exercise. Subsequent to treadmill training, ischemic stroke was induced by occluding the MCA for 1.5 h, followed by reperfusion. Six rats in each group were evaluated for neurological deficits and then sacrificed by decapitation to calculate the infarct volume. The remaining rats in each group were sacrificed to detect the level of superoxide dismutase (SOD) activity (n=6) and malondialdehyde (MDA) concentration (n=6). The results indicated that pre-ischemic exercise training reduced brain infarct volume and neurological deficits, increased SOD activity and decreased the concentration of MDA following ischemic stroke. In conclusion, treadmill exercise training prior to MCAO/reperfusion increased the antioxidant ability and decreased the oxidative damage in the brain subsequent to ischemic stroke.
publisher	D.A. Spandidos
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151673/
_version_	1613130089025765376

Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats

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