Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study

Offspring of long-lived parents have a low prevalence of cardiovascular disease in middle age. The purposes of this study were to investigate calcium scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery calcium score was measur...

Full description

Bibliographic Details
Main Authors:	Kroft, Lucia J. M., van der Bijl, Noortje, van der Grond, Jeroen, Altmann-Schneider, Irmhild, Slagboom, Pieternella E., Westendorp, Rudolf G. J., de Roos, Albert, de Craen, Antonius J. M.
Format:	Online
Language:	English
Published:	Springer Netherlands 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150887/

id	pubmed-4150887
recordtype	oai_dc
spelling	pubmed-41508872014-09-04 Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study Kroft, Lucia J. M. van der Bijl, Noortje van der Grond, Jeroen Altmann-Schneider, Irmhild Slagboom, Pieternella E. Westendorp, Rudolf G. J. de Roos, Albert de Craen, Antonius J. M. Article Offspring of long-lived parents have a low prevalence of cardiovascular disease in middle age. The purposes of this study were to investigate calcium scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery calcium score was measured in offspring of long-lived families (n = 244, 125 males) and their partners (n = 223, 96 males) who served as controls. Calcium scores were analyzed separately for sexes. Subjects were grouped by very low calcium score ≤10 and scores above 10. Nonparametric Mann-Whitney test, chi-squared tests, and logistic regression analyses were performed to determine the association between calcium scores, familial longevity, and cardiovascular risk factors. More offspring of long-lived parents had lower calcium scores than controls. In men, 34 % of offspring had score ≤10 versus 21 % of controls (odds ratio (OR) and 95 % confidence interval (CI) 2.0, 1.08–3.7, p = 0.028). In women, 70 % of offspring had score ≤10 versus 54 % of controls (OR 1.9, 95 % CI 1.13–3.4, p = 0.019). Differences remained significant after correction for age (men, p = 0.043 and women, p = 0.003) and further correction for major risk factors in women, indicating genetic influence for lower calcium scores. In men, the association was found to be influenced by cardiovascular risk factors. Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls. Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease. Springer Netherlands 2014-07-24 2014-08 /pmc/articles/PMC4150887/ /pubmed/25053439 http://dx.doi.org/10.1007/s11357-014-9668-6 Text en © The Author(s) 2014 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kroft, Lucia J. M. van der Bijl, Noortje van der Grond, Jeroen Altmann-Schneider, Irmhild Slagboom, Pieternella E. Westendorp, Rudolf G. J. de Roos, Albert de Craen, Antonius J. M.
spellingShingle	Kroft, Lucia J. M. van der Bijl, Noortje van der Grond, Jeroen Altmann-Schneider, Irmhild Slagboom, Pieternella E. Westendorp, Rudolf G. J. de Roos, Albert de Craen, Antonius J. M. Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study
author_facet	Kroft, Lucia J. M. van der Bijl, Noortje van der Grond, Jeroen Altmann-Schneider, Irmhild Slagboom, Pieternella E. Westendorp, Rudolf G. J. de Roos, Albert de Craen, Antonius J. M.
author_sort	Kroft, Lucia J. M.
title	Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study
title_short	Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study
title_full	Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study
title_fullStr	Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study
title_full_unstemmed	Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study
title_sort	low computed tomography coronary artery calcium scores in familial longevity: the leiden longevity study
description	Offspring of long-lived parents have a low prevalence of cardiovascular disease in middle age. The purposes of this study were to investigate calcium scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery calcium score was measured in offspring of long-lived families (n = 244, 125 males) and their partners (n = 223, 96 males) who served as controls. Calcium scores were analyzed separately for sexes. Subjects were grouped by very low calcium score ≤10 and scores above 10. Nonparametric Mann-Whitney test, chi-squared tests, and logistic regression analyses were performed to determine the association between calcium scores, familial longevity, and cardiovascular risk factors. More offspring of long-lived parents had lower calcium scores than controls. In men, 34 % of offspring had score ≤10 versus 21 % of controls (odds ratio (OR) and 95 % confidence interval (CI) 2.0, 1.08–3.7, p = 0.028). In women, 70 % of offspring had score ≤10 versus 54 % of controls (OR 1.9, 95 % CI 1.13–3.4, p = 0.019). Differences remained significant after correction for age (men, p = 0.043 and women, p = 0.003) and further correction for major risk factors in women, indicating genetic influence for lower calcium scores. In men, the association was found to be influenced by cardiovascular risk factors. Men and women with a familial propensity to become long-lived have lower coronary artery calcium scores than controls. Low scores may indicate a younger biologic arterial age associated with a low risk for incident cardiovascular disease.
publisher	Springer Netherlands
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150887/
_version_	1613129881604849664

Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study

Similar Items