Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis

Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a frontline anti-tuberculosis drug that plays a crucial role in the treatment of both drug-susceptible and multidrug-resistant tuberculosis (MDR-TB). PZA is a prodrug that is converted to its active form, pyrazinoic acid (POA), by a nicotinamidase/pyrazinamidase encoded by the...

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Bibliographic Details
Main Authors: Shi, Wanliang, Chen, Jiazhen, Feng, Jie, Cui, Peng, Zhang, Shuo, Weng, Xinhua, Zhang, Wenhong, Zhang, Ying
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150287/

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