MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s...

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Bibliographic Details
Main Authors: Oliphant, Christopher J., Hwang, You Yi, Walker, Jennifer A., Salimi, Maryam, Wong, See Heng, Brewer, James M., Englezakis, Alexandros, Barlow, Jillian L., Hams, Emily, Scanlon, Seth T., Ogg, Graham S., Fallon, Padraic G., McKenzie, Andrew N.J.
Format: Online
Language:English
Published: Cell Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148706/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148706/

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