Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells

Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells

Overcoming platinum drug resistance represents a major clinical challenge in cancer treatment. We discovered a novel drug combination using cisplatin and a class of thioquinazolinone derivatives including mdivi-1 (mitochondrial division inhibitor-1), that induces synergistic apoptosis in platinum re...

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Bibliographic Details
Main Authors: Qian, Wei, Wang, Jingnan, Roginskaya, Vera, McDermott, Lee A., Edwards, Robert P., Stolz, Donna B., Llambi, Fabien, Green, Douglas R., Houten, Bennett Van
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147315/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147315/

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