Impact of thyroid status and age on comprehensive geriatric assessment
This study aimed to evaluate the prevalence of thyroid dysfunction in elderly subjects attending an outpatient clinic at a tertiary hospital and to assess whether subclinical hypothyroidism (SCH) or aging affected activities of daily living (ADLs), instrumental activities of daily living (IADLs), co...
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| Format: | Online |
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Springer US
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145217/ |
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pubmed-41452172014-08-28 Impact of thyroid status and age on comprehensive geriatric assessment e Silva, Silvana Oliveira Chan, I. Thien Lobo Santos, Maryna A. Cohen, Marcela de La Roque P. Araujo, Mayra da Silva Almeida, Julia Simões, Andressa Givigi, Helder Renato B. Vaisman, Mario Paixão, Carlos M. de Fatima dos S. Teixeira, Patricia Original Article This study aimed to evaluate the prevalence of thyroid dysfunction in elderly subjects attending an outpatient clinic at a tertiary hospital and to assess whether subclinical hypothyroidism (SCH) or aging affected activities of daily living (ADLs), instrumental activities of daily living (IADLs), cognitive status, or depressive symptoms. This crosssectional study included 411 patients recruited in the outpatient geriatric setting. 48 subjects reported levothyroxine use and were evaluated separately. After excluding subjects with diseases or drugs which could influence thyroid status, the 284 subjects remaining were classified as having euthyroidism (n = 235, 82.8 %), subclinical hypothyroidism (n = 43, 15.1 %), subclinical hyperthyroidism (n = 4, 1.4 %), or overt hyperthyroidism (n = 2, 0.7 %). ADLs and IADLs were assessed using the Katz Index (ranging from 0 [independence] to 6 [dependence in all activities]) and Health Assessment Questionnaire (ranging from 0 to 3 [severely disabled]), respectively. Cognition was assessed using the mini mental state depressive symptoms that were assessed using the Geriatric depression scale or cornell scale for depression in dementia. SCH did not reduce performance in ADLs or IADLs in elderly subjects as a whole, but was an independent protective factor against dependence in ADLs (OR = 0.196 [0.045–0.853]; p = 0.003) and IADLs (OR = 0.060 [0.010–0.361]; p = 0.002) in subjects aged ≥85 years. Very old subjects with SCH showed better performance in ADLs than did those with euthyroidism (Katz Index: 0.9 ± 1.6 [median: 0.5] vs. 1.7 ± 1.7 [1.0], p = 0.024; HAQ: 1.2 ± 0.8 [0.9] vs. 1.8 ± 1.0 [1.9], p = 0.015). This putative protective effect of SCH was not found in subjects aged <85 years. The number of falls, number of medications used, depressive symptoms, and cognitive impairment did not differ among thyroid status groups, regardless of age. In conclusion, SCH does not have impact functional performance in the elderly population as a whole, but was associated with better functional status in subjects aged ≥85 years. Springer US 2013-11-01 2014 /pmc/articles/PMC4145217/ /pubmed/24178891 http://dx.doi.org/10.1007/s12020-013-0077-x Text en © The Author(s) 2013 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
e Silva, Silvana Oliveira Chan, I. Thien Lobo Santos, Maryna A. Cohen, Marcela de La Roque P. Araujo, Mayra da Silva Almeida, Julia Simões, Andressa Givigi, Helder Renato B. Vaisman, Mario Paixão, Carlos M. de Fatima dos S. Teixeira, Patricia |
| spellingShingle |
e Silva, Silvana Oliveira Chan, I. Thien Lobo Santos, Maryna A. Cohen, Marcela de La Roque P. Araujo, Mayra da Silva Almeida, Julia Simões, Andressa Givigi, Helder Renato B. Vaisman, Mario Paixão, Carlos M. de Fatima dos S. Teixeira, Patricia Impact of thyroid status and age on comprehensive geriatric assessment |
| author_facet |
e Silva, Silvana Oliveira Chan, I. Thien Lobo Santos, Maryna A. Cohen, Marcela de La Roque P. Araujo, Mayra da Silva Almeida, Julia Simões, Andressa Givigi, Helder Renato B. Vaisman, Mario Paixão, Carlos M. de Fatima dos S. Teixeira, Patricia |
| author_sort |
e Silva, Silvana Oliveira |
| title |
Impact of thyroid status and age on comprehensive geriatric assessment |
| title_short |
Impact of thyroid status and age on comprehensive geriatric assessment |
| title_full |
Impact of thyroid status and age on comprehensive geriatric assessment |
| title_fullStr |
Impact of thyroid status and age on comprehensive geriatric assessment |
| title_full_unstemmed |
Impact of thyroid status and age on comprehensive geriatric assessment |
| title_sort |
impact of thyroid status and age on comprehensive geriatric assessment |
| description |
This study aimed to evaluate the prevalence of thyroid dysfunction in elderly subjects attending an outpatient clinic at a tertiary hospital and to assess whether subclinical hypothyroidism (SCH) or aging affected activities of daily living (ADLs), instrumental activities of daily living (IADLs), cognitive status, or depressive symptoms. This crosssectional study included 411 patients recruited in the outpatient geriatric setting. 48 subjects reported levothyroxine use and were evaluated separately. After excluding subjects with diseases or drugs which could influence thyroid status, the 284 subjects remaining were classified as having euthyroidism (n = 235, 82.8 %), subclinical hypothyroidism (n = 43, 15.1 %), subclinical hyperthyroidism (n = 4, 1.4 %), or overt hyperthyroidism (n = 2, 0.7 %). ADLs and IADLs were assessed using the Katz Index (ranging from 0 [independence] to 6 [dependence in all activities]) and Health Assessment Questionnaire (ranging from 0 to 3 [severely disabled]), respectively. Cognition was assessed using the mini mental state depressive symptoms that were assessed using the Geriatric depression scale or cornell scale for depression in dementia. SCH did not reduce performance in ADLs or IADLs in elderly subjects as a whole, but was an independent protective factor against dependence in ADLs (OR = 0.196 [0.045–0.853]; p = 0.003) and IADLs (OR = 0.060 [0.010–0.361]; p = 0.002) in subjects aged ≥85 years. Very old subjects with SCH showed better performance in ADLs than did those with euthyroidism (Katz Index: 0.9 ± 1.6 [median: 0.5] vs. 1.7 ± 1.7 [1.0], p = 0.024; HAQ: 1.2 ± 0.8 [0.9] vs. 1.8 ± 1.0 [1.9], p = 0.015). This putative protective effect of SCH was not found in subjects aged <85 years. The number of falls, number of medications used, depressive symptoms, and cognitive impairment did not differ among thyroid status groups, regardless of age. In conclusion, SCH does not have impact functional performance in the elderly population as a whole, but was associated with better functional status in subjects aged ≥85 years. |
| publisher |
Springer US |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145217/ |
| _version_ |
1613127859999604736 |