Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice

Electrophysiological studies have revealed that a large proportion of the mouse primary visual cortex (V1) receives input also from the ipsilateral eye. This is surprising as most optic nerve fibers cross at the optic chiasm in mice. Inactivating V1 of one hemisphere has recently demonstrated a stro...

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Main Authors:	Dehmel, Susanne, Löwel, Siegrid
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144898/

id	pubmed-4144898
recordtype	oai_dc
spelling	pubmed-41448982014-08-29 Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice Dehmel, Susanne Löwel, Siegrid Research Article Electrophysiological studies have revealed that a large proportion of the mouse primary visual cortex (V1) receives input also from the ipsilateral eye. This is surprising as most optic nerve fibers cross at the optic chiasm in mice. Inactivating V1 of one hemisphere has recently demonstrated a strong contribution of one hemisphere's activity on binocularity of single units and visually evoked potentials of V1 in the other hemisphere of young rats and of single units in young adult mice. Here we used intrinsic signal optical imaging to quantitatively study the influence of cortico-cortical connections on the magnitude of neuronal activation in the entire binocular zone of adult mouse V1. We simultaneously measured V1-activity of both hemispheres in adult C57BL/6J mice before and after blocking sensory-driven activity in one hemisphere with muscimol. In V1 contralateral to the inactivation, ipsilateral eye evoked activity was reduced by on average 18% while contralateral eye evoked activity did not change. Our results clearly show that cortico-cortical interactions exert a global amplification of ipsilateral eye evoked activity in adult mouse V1. Public Library of Science 2014-08-26 /pmc/articles/PMC4144898/ /pubmed/25157503 http://dx.doi.org/10.1371/journal.pone.0105745 Text en © 2014 Dehmel, Löwel http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Dehmel, Susanne Löwel, Siegrid
spellingShingle	Dehmel, Susanne Löwel, Siegrid Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice
author_facet	Dehmel, Susanne Löwel, Siegrid
author_sort	Dehmel, Susanne
title	Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice
title_short	Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice
title_full	Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice
title_fullStr	Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice
title_full_unstemmed	Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice
title_sort	cortico-cortical interactions influence binocularity of the primary visual cortex of adult mice
description	Electrophysiological studies have revealed that a large proportion of the mouse primary visual cortex (V1) receives input also from the ipsilateral eye. This is surprising as most optic nerve fibers cross at the optic chiasm in mice. Inactivating V1 of one hemisphere has recently demonstrated a strong contribution of one hemisphere's activity on binocularity of single units and visually evoked potentials of V1 in the other hemisphere of young rats and of single units in young adult mice. Here we used intrinsic signal optical imaging to quantitatively study the influence of cortico-cortical connections on the magnitude of neuronal activation in the entire binocular zone of adult mouse V1. We simultaneously measured V1-activity of both hemispheres in adult C57BL/6J mice before and after blocking sensory-driven activity in one hemisphere with muscimol. In V1 contralateral to the inactivation, ipsilateral eye evoked activity was reduced by on average 18% while contralateral eye evoked activity did not change. Our results clearly show that cortico-cortical interactions exert a global amplification of ipsilateral eye evoked activity in adult mouse V1.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144898/
_version_	1613127771984232448

Cortico-Cortical Interactions Influence Binocularity of the Primary Visual Cortex of Adult Mice

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