Mechanisms of action of therapeutic amyloidogenic hexapeptides in amelioration of inflammatory brain disease
Immunosuppression from amyloidogenic peptides arises from two pathways, expression of type 1 IFN by pDCs and reduced expression of IFN-γ, TNF, and IL-6, which together modulate the signs of both Th1- and Th17-induced EAE.
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144739/ |