Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour

Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour

Wilms tumour is a childhood kidney cancer. Here we identify inactivating CTR9 mutations in 3 of 35 Wilms tumour families, through exome and Sanger sequencing. By contrast, no similar mutations are present in 1,000 population controls (P<0.0001). Each mutation segregates with Wilms tumour in the f...

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Bibliographic Details
Main Authors: Hanks, Sandra, Perdeaux, Elizabeth R., Seal, Sheila, Ruark, Elise, Mahamdallie, Shazia S., Murray, Anne, Ramsay, Emma, Del Vecchio Duarte, Silvana, Zachariou, Anna, de Souza, Bianca, Warren-Perry, Margaret, Elliott, Anna, Davidson, Alan, Price, Helen, Stiller, Charles, Pritchard-Jones, Kathy, Rahman, Nazneen
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143912/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143912/

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