Gossypol Promotes Degeneration of Ovarian Follicles in Rats
The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classifi...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142328/ |
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pubmed-4142328 |
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pubmed-41423282014-12-24 Gossypol Promotes Degeneration of Ovarian Follicles in Rats Gadelha, Ivana Cristina Nunes Fernandes de Macedo, Michelly Oloris, Sílvia Catarina Salgado Melo, Marilia Martins Soto-Blanco, Benito Research Article The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classified according to the stage of development and as normal or atretic. Gossypol treatment reduced the length of estrous with an increase in the duration of the diestrus phase. This compound was responsible for reduced serum levels of T4 and progesterone. Treatment with gossypol was responsible for a significant reduction in the number of normal ovarian follicles and a significant increase in the number of atretic follicles, both in all stages of development. Thus, treatment of rats with gossypol was responsible for reduction in the number of viable follicles and changes in hormone levels that resulted in interference of the estrous cycle. Hindawi Publishing Corporation 2014 2014-07-23 /pmc/articles/PMC4142328/ /pubmed/25540815 http://dx.doi.org/10.1155/2014/986184 Text en Copyright © 2014 Ivana Cristina Nunes Gadelha et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Gadelha, Ivana Cristina Nunes Fernandes de Macedo, Michelly Oloris, Sílvia Catarina Salgado Melo, Marilia Martins Soto-Blanco, Benito |
| spellingShingle |
Gadelha, Ivana Cristina Nunes Fernandes de Macedo, Michelly Oloris, Sílvia Catarina Salgado Melo, Marilia Martins Soto-Blanco, Benito Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| author_facet |
Gadelha, Ivana Cristina Nunes Fernandes de Macedo, Michelly Oloris, Sílvia Catarina Salgado Melo, Marilia Martins Soto-Blanco, Benito |
| author_sort |
Gadelha, Ivana Cristina Nunes |
| title |
Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_short |
Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_full |
Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_fullStr |
Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_full_unstemmed |
Gossypol Promotes Degeneration of Ovarian Follicles in Rats |
| title_sort |
gossypol promotes degeneration of ovarian follicles in rats |
| description |
The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classified according to the stage of development and as normal or atretic. Gossypol treatment reduced the length of estrous with an increase in the duration of the diestrus phase. This compound was responsible for reduced serum levels of T4 and progesterone. Treatment with gossypol was responsible for a significant reduction in the number of normal ovarian follicles and a significant increase in the number of atretic follicles, both in all stages of development. Thus, treatment of rats with gossypol was responsible for reduction in the number of viable follicles and changes in hormone levels that resulted in interference of the estrous cycle. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142328/ |
| _version_ |
1613126965195177984 |