Optimizing real time fMRI neurofeedback for therapeutic discovery and development

While reducing the burden of brain disorders remains a top priority of organizations like the World Health Organization and National Institutes of Health, the development of novel, safe and effective treatments for brain disorders has been slow. In this paper, we describe the state of the science fo...

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Main Authors:	Stoeckel, L.E., Garrison, K.A., Ghosh, S., Wighton, P., Hanlon, C.A., Gilman, J.M., Greer, S., Turk-Browne, N.B., deBettencourt, M.T., Scheinost, D., Craddock, C., Thompson, T., Calderon, V., Bauer, C.C., George, M., Breiter, H.C., Whitfield-Gabrieli, S., Gabrieli, J.D., LaConte, S.M., Hirshberg, L., Brewer, J.A., Hampson, M., Van Der Kouwe, A., Mackey, S., Evins, A.E.
Format:	Online
Language:	English
Published:	Elsevier 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141981/

id	pubmed-4141981
recordtype	oai_dc
spelling	pubmed-41419812014-08-26 Optimizing real time fMRI neurofeedback for therapeutic discovery and development Stoeckel, L.E. Garrison, K.A. Ghosh, S. Wighton, P. Hanlon, C.A. Gilman, J.M. Greer, S. Turk-Browne, N.B. deBettencourt, M.T. Scheinost, D. Craddock, C. Thompson, T. Calderon, V. Bauer, C.C. George, M. Breiter, H.C. Whitfield-Gabrieli, S. Gabrieli, J.D. LaConte, S.M. Hirshberg, L. Brewer, J.A. Hampson, M. Van Der Kouwe, A. Mackey, S. Evins, A.E. Article While reducing the burden of brain disorders remains a top priority of organizations like the World Health Organization and National Institutes of Health, the development of novel, safe and effective treatments for brain disorders has been slow. In this paper, we describe the state of the science for an emerging technology, real time functional magnetic resonance imaging (rtfMRI) neurofeedback, in clinical neurotherapeutics. We review the scientific potential of rtfMRI and outline research strategies to optimize the development and application of rtfMRI neurofeedback as a next generation therapeutic tool. We propose that rtfMRI can be used to address a broad range of clinical problems by improving our understanding of brain–behavior relationships in order to develop more specific and effective interventions for individuals with brain disorders. We focus on the use of rtfMRI neurofeedback as a clinical neurotherapeutic tool to drive plasticity in brain function, cognition, and behavior. Our overall goal is for rtfMRI to advance personalized assessment and intervention approaches to enhance resilience and reduce morbidity by correcting maladaptive patterns of brain function in those with brain disorders. Elsevier 2014-07-10 /pmc/articles/PMC4141981/ /pubmed/25161891 http://dx.doi.org/10.1016/j.nicl.2014.07.002 Text en © 2014 The Authors. Published by Elsevier Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Stoeckel, L.E. Garrison, K.A. Ghosh, S. Wighton, P. Hanlon, C.A. Gilman, J.M. Greer, S. Turk-Browne, N.B. deBettencourt, M.T. Scheinost, D. Craddock, C. Thompson, T. Calderon, V. Bauer, C.C. George, M. Breiter, H.C. Whitfield-Gabrieli, S. Gabrieli, J.D. LaConte, S.M. Hirshberg, L. Brewer, J.A. Hampson, M. Van Der Kouwe, A. Mackey, S. Evins, A.E.
spellingShingle	Stoeckel, L.E. Garrison, K.A. Ghosh, S. Wighton, P. Hanlon, C.A. Gilman, J.M. Greer, S. Turk-Browne, N.B. deBettencourt, M.T. Scheinost, D. Craddock, C. Thompson, T. Calderon, V. Bauer, C.C. George, M. Breiter, H.C. Whitfield-Gabrieli, S. Gabrieli, J.D. LaConte, S.M. Hirshberg, L. Brewer, J.A. Hampson, M. Van Der Kouwe, A. Mackey, S. Evins, A.E. Optimizing real time fMRI neurofeedback for therapeutic discovery and development
author_facet	Stoeckel, L.E. Garrison, K.A. Ghosh, S. Wighton, P. Hanlon, C.A. Gilman, J.M. Greer, S. Turk-Browne, N.B. deBettencourt, M.T. Scheinost, D. Craddock, C. Thompson, T. Calderon, V. Bauer, C.C. George, M. Breiter, H.C. Whitfield-Gabrieli, S. Gabrieli, J.D. LaConte, S.M. Hirshberg, L. Brewer, J.A. Hampson, M. Van Der Kouwe, A. Mackey, S. Evins, A.E.
author_sort	Stoeckel, L.E.
title	Optimizing real time fMRI neurofeedback for therapeutic discovery and development
title_short	Optimizing real time fMRI neurofeedback for therapeutic discovery and development
title_full	Optimizing real time fMRI neurofeedback for therapeutic discovery and development
title_fullStr	Optimizing real time fMRI neurofeedback for therapeutic discovery and development
title_full_unstemmed	Optimizing real time fMRI neurofeedback for therapeutic discovery and development
title_sort	optimizing real time fmri neurofeedback for therapeutic discovery and development
description	While reducing the burden of brain disorders remains a top priority of organizations like the World Health Organization and National Institutes of Health, the development of novel, safe and effective treatments for brain disorders has been slow. In this paper, we describe the state of the science for an emerging technology, real time functional magnetic resonance imaging (rtfMRI) neurofeedback, in clinical neurotherapeutics. We review the scientific potential of rtfMRI and outline research strategies to optimize the development and application of rtfMRI neurofeedback as a next generation therapeutic tool. We propose that rtfMRI can be used to address a broad range of clinical problems by improving our understanding of brain–behavior relationships in order to develop more specific and effective interventions for individuals with brain disorders. We focus on the use of rtfMRI neurofeedback as a clinical neurotherapeutic tool to drive plasticity in brain function, cognition, and behavior. Our overall goal is for rtfMRI to advance personalized assessment and intervention approaches to enhance resilience and reduce morbidity by correcting maladaptive patterns of brain function in those with brain disorders.
publisher	Elsevier
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141981/
_version_	1613126878983356416

Optimizing real time fMRI neurofeedback for therapeutic discovery and development

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