Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

•Colonic crypts with mitochondrial dysfunction accumulate with age in PolgA+/mut mice.•Mitochondrial dysfunction is caused by clonally expanded mtDNA point mutations.•The mutations are random and their expansion is not subject to selective constraints.•Colonic crypts of aged humans have a similar mt...

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Bibliographic Details
Main Authors: Baines, Holly L., Stewart, James B., Stamp, Craig, Zupanic, Anze, Kirkwood, Thomas B.L., Larsson, Nils-Göran, Turnbull, Douglass M., Greaves, Laura C.
Format: Online
Language:English
Published: Elsevier Science Ireland 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141908/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141908/

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