Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2

Cholangiocarcinoma (CCA) is an often fatal primary malignancy of the intra- and extrahepatic biliary tract that is commonly associated with chronic cholestasis and significantly elevated levels of primary and conjugated bile acids (CBAs), which are correlated with bile duct obstruction (BDO). BDO ha...

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Bibliographic Details
Main Authors: Liu, Runping, Zhao, Renping, Zhou, Xiqiao, Liang, Xiuyin, Campbell, Deanna JW, Zhang, Xiaoxuan, Zhang, Luyong, Shi, Ruihua, Wang, Guangji, Pandak, William M, Sirica, Alphonse E, Hylemon, Phillip B, Zhou, Huiping
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141906/