The functional diversity of essential genes required for mammalian cardiac development

Genes required for an organism to develop to maturity (for which no other gene can compensate) are considered essential. The continuing functional annotation of the mouse genome has enabled the identification of many essential genes required for specific developmental processes including cardiac dev...

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Main Authors:	Clowes, Christopher, Boylan, Michael GS, Ridge, Liam A, Barnes, Emma, Wright, Jayne A, Hentges, Kathryn E
Format:	Online
Language:	English
Published:	BlackWell Publishing Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141749/

id	pubmed-4141749
recordtype	oai_dc
spelling	pubmed-41417492014-09-08 The functional diversity of essential genes required for mammalian cardiac development Clowes, Christopher Boylan, Michael GS Ridge, Liam A Barnes, Emma Wright, Jayne A Hentges, Kathryn E Review Genes required for an organism to develop to maturity (for which no other gene can compensate) are considered essential. The continuing functional annotation of the mouse genome has enabled the identification of many essential genes required for specific developmental processes including cardiac development. Patterns are now emerging regarding the functional nature of genes required at specific points throughout gestation. Essential genes required for development beyond cardiac progenitor cell migration and induction include a small and functionally homogenous group encoding transcription factors, ligands and receptors. Actions of core cardiogenic transcription factors from the Gata, Nkx, Mef, Hand, and Tbx families trigger a marked expansion in the functional diversity of essential genes from midgestation onwards. As the embryo grows in size and complexity, genes required to maintain a functional heartbeat and to provide muscular strength and regulate blood flow are well represented. These essential genes regulate further specialization and polarization of cell types along with proliferative, migratory, adhesive, contractile, and structural processes. The identification of patterns regarding the functional nature of essential genes across numerous developmental systems may aid prediction of further essential genes and those important to development and/or progression of disease. genesis 52:713–737, 2014. BlackWell Publishing Ltd 2014-08 2014-06-24 /pmc/articles/PMC4141749/ /pubmed/24866031 http://dx.doi.org/10.1002/dvg.22794 Text en © 2014 The Authors. Genesis Published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Clowes, Christopher Boylan, Michael GS Ridge, Liam A Barnes, Emma Wright, Jayne A Hentges, Kathryn E
spellingShingle	Clowes, Christopher Boylan, Michael GS Ridge, Liam A Barnes, Emma Wright, Jayne A Hentges, Kathryn E The functional diversity of essential genes required for mammalian cardiac development
author_facet	Clowes, Christopher Boylan, Michael GS Ridge, Liam A Barnes, Emma Wright, Jayne A Hentges, Kathryn E
author_sort	Clowes, Christopher
title	The functional diversity of essential genes required for mammalian cardiac development
title_short	The functional diversity of essential genes required for mammalian cardiac development
title_full	The functional diversity of essential genes required for mammalian cardiac development
title_fullStr	The functional diversity of essential genes required for mammalian cardiac development
title_full_unstemmed	The functional diversity of essential genes required for mammalian cardiac development
title_sort	functional diversity of essential genes required for mammalian cardiac development
description	Genes required for an organism to develop to maturity (for which no other gene can compensate) are considered essential. The continuing functional annotation of the mouse genome has enabled the identification of many essential genes required for specific developmental processes including cardiac development. Patterns are now emerging regarding the functional nature of genes required at specific points throughout gestation. Essential genes required for development beyond cardiac progenitor cell migration and induction include a small and functionally homogenous group encoding transcription factors, ligands and receptors. Actions of core cardiogenic transcription factors from the Gata, Nkx, Mef, Hand, and Tbx families trigger a marked expansion in the functional diversity of essential genes from midgestation onwards. As the embryo grows in size and complexity, genes required to maintain a functional heartbeat and to provide muscular strength and regulate blood flow are well represented. These essential genes regulate further specialization and polarization of cell types along with proliferative, migratory, adhesive, contractile, and structural processes. The identification of patterns regarding the functional nature of essential genes across numerous developmental systems may aid prediction of further essential genes and those important to development and/or progression of disease. genesis 52:713–737, 2014.
publisher	BlackWell Publishing Ltd
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141749/
_version_	1613126781957570560

The functional diversity of essential genes required for mammalian cardiac development

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