Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses
Vibrio cholerae is the bacterium that causes cholera, which can be a potentially fatal diarrheal disease that affects millions of people worldwide each year. How our immune system provides protection against cholera is poorly understood. Mucosal Associated Invariant T (MAIT) cells are recently disc...
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Public Library of Science
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140671/ |
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pubmed-4140671 |
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pubmed-41406712014-08-25 Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses Leung, Daniel T. Bhuiyan, Taufiqur R. Nishat, Naoshin S. Hoq, Mohammad Rubel Aktar, Amena Rahman, M. Arifur Uddin, Taher Khan, Ashraful I. Chowdhury, Fahima Charles, Richelle C. Harris, Jason B. Calderwood, Stephen B. Qadri, Firdausi Ryan, Edward T. Research Article Vibrio cholerae is the bacterium that causes cholera, which can be a potentially fatal diarrheal disease that affects millions of people worldwide each year. How our immune system provides protection against cholera is poorly understood. Mucosal Associated Invariant T (MAIT) cells are recently discovered immune cells found in the blood and intestinal tract of humans. In this study of cholera patients in Dhaka, Bangladesh, we found that blood MAIT cells are activated during cholera, and that in children, blood MAIT cells are decreased in number during the course of disease. We also found that the MAIT cell response correlates with the antibody response to V. cholerae O1 lipopolysaccharide, which in the past has been shown to be an important determinant of protection. These findings suggest that MAIT cells may play an important role in the body's defense against cholera. Public Library of Science 2014-08-21 /pmc/articles/PMC4140671/ /pubmed/25144724 http://dx.doi.org/10.1371/journal.pntd.0003076 Text en © 2014 Leung et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Leung, Daniel T. Bhuiyan, Taufiqur R. Nishat, Naoshin S. Hoq, Mohammad Rubel Aktar, Amena Rahman, M. Arifur Uddin, Taher Khan, Ashraful I. Chowdhury, Fahima Charles, Richelle C. Harris, Jason B. Calderwood, Stephen B. Qadri, Firdausi Ryan, Edward T. |
| spellingShingle |
Leung, Daniel T. Bhuiyan, Taufiqur R. Nishat, Naoshin S. Hoq, Mohammad Rubel Aktar, Amena Rahman, M. Arifur Uddin, Taher Khan, Ashraful I. Chowdhury, Fahima Charles, Richelle C. Harris, Jason B. Calderwood, Stephen B. Qadri, Firdausi Ryan, Edward T. Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses |
| author_facet |
Leung, Daniel T. Bhuiyan, Taufiqur R. Nishat, Naoshin S. Hoq, Mohammad Rubel Aktar, Amena Rahman, M. Arifur Uddin, Taher Khan, Ashraful I. Chowdhury, Fahima Charles, Richelle C. Harris, Jason B. Calderwood, Stephen B. Qadri, Firdausi Ryan, Edward T. |
| author_sort |
Leung, Daniel T. |
| title |
Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses |
| title_short |
Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses |
| title_full |
Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses |
| title_fullStr |
Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses |
| title_full_unstemmed |
Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses |
| title_sort |
circulating mucosal associated invariant t cells are activated in vibrio cholerae o1 infection and associated with lipopolysaccharide antibody responses |
| description |
Vibrio cholerae is the bacterium that causes cholera, which can be a potentially fatal diarrheal disease that affects millions of people worldwide each year. How our immune system provides protection against cholera is poorly understood. Mucosal Associated Invariant T (MAIT) cells are recently discovered immune cells found in the blood and intestinal tract of humans. In this study of cholera patients in Dhaka, Bangladesh, we found that blood MAIT cells are activated during cholera, and that in children, blood MAIT cells are decreased in number during the course of disease. We also found that the MAIT cell response correlates with the antibody response to V. cholerae O1 lipopolysaccharide, which in the past has been shown to be an important determinant of protection. These findings suggest that MAIT cells may play an important role in the body's defense against cholera. |
| publisher |
Public Library of Science |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140671/ |
| _version_ |
1613126434816000000 |